5803-92-9

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 100-53-8 phenylmethanethiol 
• 463-58-1 carbon oxide sulfide 
• 28269-82-1 phenyl S-benzylisothiocarbamide 
• 100-44-7 benzyl chloride 
• 620-05-3 iodomethylbenzene 
• 75-15-0 carbon disulfide 
• 62-53-3 aniline 

Downstream Products

• 103-72-0 phenyl isothiocyanate 
• 100-53-8 phenylmethanethiol 
• 115197-97-2 C₂₀H₁₇NS₂ 
• 115197-99-4 C₂₁H₁₉NS₂ 
• 115197-98-3 C₂₀H₁₆N₂O₂S₂ 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 62-53-3 aniline 
• 102-08-9 N,N-diphenylthiourea 
• 18805-24-8 phenyl dithiocarbimidoic acid dibenzyl ester 
• 2209-59-8 1,6-diphenyl-dithiodiurea 
• 1152-54-1 N,N-diphenyl-[1,3,4]thiadiazole-2,5-diamine 

Relevant academic research and scientific papers

Synthesis of bioactive polyaniline- b -polyacrylic acid copolymer nanofibrils as an effective antibacterial and anticancer agent in cancer therapy, especially for HT29 treatment

In this work, a new highly water-soluble copolymer of polyacrylic acid with polyaniline is introduced. Acrylic acid was polymerized via the Reversible Addition Fragmentation Chain Transfer method (RAFT) in the presence of an initiator and the obtained polyacrylic acid was copolymerized with aniline at room temperature. As the main achievements of this work, the resulting block copolymer with nanosized structure revealed favorable solubility in polar solvents, as well as excellent antibacterial and anticancer activities. Therefore, it is an appropriate candidate for medical applications such as wound healing and cancer therapy, especially in HT29 treatment.

Addition of Thiols to Isocyanates Catalyzed by Simple Rare-Earth-Metal Amides: Synthesis of S-Alkyl Thiocarbamates and Dithiocarbamates

Simple additions of thiols to isocyanates/isothiocyanates under mild conditions led to the efficient preparation of various S-alkyl thiocarbamates and dithiocarbamates, respectively. The lanthanum complex La[N(SiMe3)2]3 wa

Investigations into the carbonic anhydrase inhibition of COS-releasing donor core motifs

Carbonyl sulfide (COS) releasing scaffolds are gaining popularity as hydrogen sulfide (H2S) donors through exploitation of the carbonic anhydrase (CA)-mediated hydrolysis of COS to H2S. The majority of compounds in this emerging class of donors undergo triggerable decomposition (often referred to as self-immolation) to release COS, and a handful of different COS-releasing structures have been reported. One benefit of this donation strategy is that numerous caged COS-containing core motifs are possible and are poised for development into self-immolative COS/H2S donors. Because the intermediate release of COS en route to H2S donation requires CA, it is important that the COS donor motifs do not inhibit CA directly. In this work, we investigate the cytotoxicity and CA inhibition properties of different caged COS donor cores, as well as caged CO2 and CS2 motifs and non-self-immolative control compounds. None of the compounds investigated exhibited significant cytotoxicity or enhanced cell proliferation at concentrations up to 100 μM in A549 cells, but we identified four core structures that function as CA inhibitors, thus providing a roadmap for the future development of self-immolative COS/H2S donor motifs.

Method for catalyzing addition reaction of phenyl isocyanate or phenyl isothiocyanate with thiol

The invention relates to a method for catalyzing addition reaction of phenyl isocyanate or phenyl isothiocyanate with thiol. The method for catalyzing the addition reaction of the phenyl isocyanate orthe phenyl isothiocyanate with the thiol includes the s

Addition of E-H (E = N, P, C, O, S) Bonds to Heterocumulenes Catalyzed by Benzimidazolin-2-iminato Actinide Complexes

The synthesis and characterization of benzimidazolin-2-iminato actinide(IV) complexes [(BimR1/R2N)An(N{SiMe3}2)3] (An = U, Th) (1-6) is reported. All complexes were obtained in high yields, and their solid state structures were established through single-crystal X-ray diffraction analysis. Using 1-6 as precatalysts, the addition of mono- and bifunctional E-H (E = N, P, C, O, S) substrates to various heterocumulenes, including carbodiimides, isocyanates, and isothiocyanates, was investigated, affording the respective addition products in high yields under very mild reaction conditions. Various amines were applicable to this reaction, indicating a large scope capability of amine nucleophiles for the insertion process.

Catalytic insertion of E-H bonds (E = C, N, P, S) into heterocumulenes by amido-actinide complexes

We report herein the actinide-mediated insertion of E-H bonds (E = C, N, P, S) into various heterocumulenes including carbodiimides, isocyanates, and isothiocyanates. The precatalysts are prepared by a simple, one-pot procedure using readily available sta

Actinide-Mediated Catalytic Addition of E-H Bonds (E=N, P, S) to Carbodiimides, Isocyanates, and Isothiocyanates

Unprecedented catalytic reactivity of actinide coordination complexes toward heterocumulenes, such as carbodiimides, isocyanates, and isothiocyanates is reported. The mono(imidazolin-2-iminato) thorium(IV) complex [Th(ImDippN){N(SiMe3)2}3] (1) was applied as a precatalyst for the addition of E-H (E=N, P, S) bonds to the Y≡C≡X core (Y=R2N; X=NR2, O, S) of carbodiimides, isocyanates, and isothiocyanates. The respective insertion products were obtained in high yields under mild reaction conditions, with complex 1 displaying high tolerance toward functional groups and heteroatoms. New reactivity: The mono(imidazolin-2-iminato) thorium complex [Th(ImDippN){N(SiMe3)2}3] was successfully applied as an active catalyst for the addition of E-H (E=N, P, S) bonds across the central Y≡N≡C≡X linkage of carbodiimides, isocyanates and isothiocyanates, yielding the respective insertion products in high yields and under mild reaction conditions.

A mild radical method for the dimerization of dithiocarbamates

A general, practical, and efficient method for the dimerization of dithiocarbamates has been developed that can be used to prepare the corresponding bis(1-arylimino-1-alkyl/ arylthiomethyl) disulfides with dilauroyl peroxide (DLP) as mild oxidant. Notably, a lauroyl radical, rather than an undecyl radical, was established as the radical hydrogen-ab- stractor during the dimerization process. The amount of DLP impacts the dimerization yield, with 50 mol-% DLP giving the disulfides in the highest yields. The use of an excess of DLP generates the undecyl radical, which decomposes the disulfides rapidly to the corresponding isothiocyanates.

Dithioallophanic Acids. Part-III: Interaction of Carbon Oxysulphide with 2-S-benzyl-1,1-Dimethyl/1-Phenyl Isothiocarbamides

Interaction of carbon oxysulphide with 2-S-benyl-1,1-dimethtyl isothiocarbamide in benzene has been found to afford 1,1-dimethyl thiocarbamide thiocyanate, S-benzyl-N,N-dimethyl thiocarbamate, and S-benzyl-N,N-dimethyl dithiocarbamate. 2-S-Benzyl-1-phenyl isothiocarbamide also affords the corresponding thiocarbamate, dithiocarbamate and in addition phenyl thiocarbamide.Mechanism has been discussed in detail.