220959-91-1

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 4870-31-9 5-(phenylamino)pyrimidine-2,4(1H,3H)-dione 
• 62-53-3 aniline 

Downstream Products

• 1261109-59-4 1-(3-phenoxybenzyl)-5-(phenylamino)uracil 
• 1261109-57-2 1-(3,5-dimethylbenzyl)-5-(phenylamino)uracil 
• 1261109-56-1 1-(3-methylbenzyl)-5-(phenylamino)uracil 
• 1261109-54-9 1-benzyl-5-(phenylamino)uracil 
• 1261109-55-0 1-(2-methylbenzyl)-5-(phenylamino)uracil 
• 1261109-58-3 1-(3-chlorobenzyl)-5-(phenylamino)uracil 

Relevant academic research and scientific papers

Synthesis of 1-(aryloxyalkyl)-5-(arylamino)uracils

In an attempt to obtain new non-nucleoside inhibitors of the reverse transcriptase HIV-1, we have carried out the synthesis of 1-(benzyloxymethyl)- and 1-[2-(4-R-phenoxy)ethyl]-5-(arylamino)uracils. Indirect alkylation of trimethylsilyl derivatives of 5-(arylamino)uracils with benzyl chloromethyl ether by the Gilbert-Jones method did not affect the exocyclic amino group and gave the corresponding 1-(benzyloxymethyl) derivatives in 58-74% yield. Alkylation of 5-(arylamino)uracils with 1-bromo-2-(4-R-phenoxy)ethane in anhydrous DMF in the presence of potassium carbonate gave a mixture of N1-mono- and N1,N1-disubstituted products with an overall yield of 46-55%. 1998 Plenum Publishing Corporation.

Acyclic analogs of pyrimidine nucleosides. Synthesis of 1-(2-hydroxyethoxymethyl)- and 1-(4-hydroxybutyl)-5-amino derivatives of uracil

With the objective of discovering new antiviral agents based on acyclic analogs of pyrimidine nucleosides, we have synthesized 1-(2-hydroxyethoxymethyl)- and 1-(4-hydroxybutyl) derivatives of uracil having various aromatic and heterocyclic amino-containing substituents in the 5 position of the pyrimidine ring. 1999 Kluwer Academic/Plenum Publishers.