220969-66-4

Upstream product

• 32933-03-2 ethyl 1-acetylcyclopropanecarboxylate 
• 1279116-77-6 ethyl 1-(2-azidoacetyl)cyclopropanecarboxylate 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 328405-08-9 ethyl 1-[2-(benzyloxycarbonylamino)-1-hydroxyethyl]-cyclopropanecarboxylate 
• 328405-10-3 (S)-ethyl 1-(1-azido-2-{[(benzyloxy)carbonyl]amino}ethyl)cyclopropanecarboxylate 

Relevant academic research and scientific papers

Synthesis of (S)-7-amino-5-azaspiro[2.4]heptane via highly enantioselective hydrogenation of protected ethyl 1-(2-aminoaceto)cyclopropanecarboxylates

Highly effective asymmetric hydrogenation of protected ethyl 1-(2-aminoaceto)cyclopropane carboxylates in the presence of [RuCl(benzene)(S)-SunPhos]Cl was realized, and high enantioselectivities (up to 98.7% ee) were obtained. This asymmetric hydrogenation provides a key intermediate for the enantioselective synthesis of (S)-7-amino-5-azaspiro[2.4] heptane moiety of quinolone antibacterial agents.