328405-08-9Relevant academic research and scientific papers
Synthesis of (S)-7-amino-5-azaspiro[2.4]heptane via highly enantioselective hydrogenation of protected ethyl 1-(2-aminoaceto)cyclopropanecarboxylates
Yao, Ying,Fan, Weizheng,Li, Wanfang,Ma, Xin,Zhu, Lvfeng,Xie, Xiaomin,Zhang, Zhaoguo
, p. 2807 - 2813 (2011/06/19)
Highly effective asymmetric hydrogenation of protected ethyl 1-(2-aminoaceto)cyclopropane carboxylates in the presence of [RuCl(benzene)(S)-SunPhos]Cl was realized, and high enantioselectivities (up to 98.7% ee) were obtained. This asymmetric hydrogenation provides a key intermediate for the enantioselective synthesis of (S)-7-amino-5-azaspiro[2.4] heptane moiety of quinolone antibacterial agents.
