220974-57-2Relevant articles and documents
Synthesis and transglycosylase-inhibiting properties of a disaccharide analogue of moenomycin a lacking substitution at C-4 of unit F
Riedel, Sylvia,Donnerstag, Astrid,Hennig, Lothar,Welzel, Peter,Richter, Joachim,Hobert, Kurt,Mueller, Dietrich,Van Heijenoort, Jean
, p. 1921 - 1936 (1999)
A disaccharide analogue (A4 = 13c) of moenomycin A lacking the OH group in the 4-position of the uronic acid moiety has been synthesized using the Saito deoxygenation reaction as key step. 13c does not inhibit the transglycosylase (PBP 1b), a key enzyme in the biosynthesis of bacterial peptidoglycan. The result demonstrates the importance of this OH group for the binding of disaccharide moenomycin analogues to the enzyme.