221001-53-2Relevant academic research and scientific papers
Discrimination of enantiotopic iodine atoms by an iodine/magnesium exchange reaction
Schulze, Volker,Hoffmann, Reinhard W.
, p. 337 - 344 (1999)
An enantioselective iodine/magnesium exchange reaction between the diiodoalkane 4 and a chiral Grignard reagent 12 has been realized at -78°C in THF. The resulting α-iodoalkylmagnesium reagents 13 are configurationally stable under these conditions and during trapping by a benzaldehyde/dimethylaluminium chloride system to furnish the iodohydrins 19 and epoxides 9.
