37763-22-7

Basic information

• Product Name: D-Leucine, ethyl ester
• CAS NO: 37763-22-7
• Molecular Formula: C8H17NO2
• Molecular Weight: 159.228
• Mol File: 37763-22-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: D-Leucine, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: D-Leucine, ethyl ester(37763-22-7)
• EPA Substance Registry System: D-Leucine, ethyl ester(37763-22-7)

Safety Data

• Hazardous Substances Data: 37763-22-7(Hazardous Substances Data)

Upstream product

• 2899-43-6 DL-leucine ethyl ester 
• 64-17-5 ethanol 
• 328-38-1 (R)-leucine 
• 140170-79-2 (R)-2-[Benzyl-((R)-2-hydroxy-1-phenyl-ethyl)-amino]-4-methyl-pentanoic acid ethyl ester 
• 221035-63-8 2-(Benzhydrylidene-amino)-4-methyl-pentanoic acid ethyl ester 
• 2743-60-4 L-Leucine ethyl ester 

Downstream Products

• 7533-40-6 2-amino-4-methyl-1-pentanol 
• 1195144-54-7 N-benzoyl-D-leucine amide 
• 73976-66-6 N-[(R)-1-((S)-1-Hydrazinocarbonyl-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]-nicotinamide 
• 73976-69-9 N-((R)-1-{(S)-1-[1-(4-Hydroxy-phenyl)-meth-(E)-ylidene-hydrazinocarbonyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethyl)-nicotinamide 
• 73976-72-4 (S)-4-Methyl-2-{(R)-3-phenyl-2-[(pyridine-3-carbonyl)-amino]-propionylamino}-pentanoic acid 
• 73976-55-3 (S)-4-Methyl-2-{(R)-3-phenyl-2-[(pyridine-3-carbonyl)-amino]-propionylamino}-pentanoic acid ethyl ester 
• 81571-25-7 C₅₂H₇₁N₅O₉ 

Relevant articles and documents

Reductive Alkylation of Amines with Carboxylic Ortho Esters

We have demonstrated for the first time that carboxylic ortho esters could be used as an alkylating agent in the reductive alkylation of amines. A variety of amines, including amino acid esters, were alkylated affording mono-alkylated products with high selectivity in practical to high yields using standard heterogeneous catalysts. By applying acyclic ortho esters alkylation was completed at room temperature. (Figure presented.).

Stereospecific Synthesis of 3,4-Dihydro-2 H-naphtho-1,4-oxazin-2-ones by Unification of Benzoxepine-4-carboxylates with Chiral Amino Acid Ethyl Esters

A novel and efficient stereocontrolled method has been developed for the preparation of chiral 3,4-dihydro-2H-naphtho[1,2-b][1,4]oxazin-2-ones by the reaction of benzoxepine-4-carboxylates with chiral amino acid ethyl esters for the first time. The chiral 3,4-dihydro-2H-naphtho-1,4-oxazinones have been achieved in one step by the formation of C-N, C-C, and C-O bonds.

Stereochemistry and conformation of skyllamycin, a non-ribosomally synthesized peptide from streptomyces sp. Acta 2897

Skyllamycin is a non-ribosomally synthesized cyclic depsipeptide from Streptomyces sp. Acta 2897 that inhibits PDGF-signaling. The peptide scaffold contains an N-terminal cinnamoyl moiety, a β-methylation of aspartic acid, three β-hydroxylated amino acids and one rarely occurring α-hydroxy glycine. With the exception of α-hydroxy glycine, the stereochemistry of the amino acids was assigned by comparison to synthetic reference amino acids applying chiral GC-MS and Marfey-HPLC analysis. The stereochemistry of α-hydroxy glycine, which is unstable under basic and acidic conditions, was determined by conformational analysis, employing a combination of data from NOESY-NMR spectroscopy, simulated annealing and free MD simulations. The simulation procedures were applied for both R- and S-configured α-hydroxy glycine of the skyllamycin structure and compared to the NOESY data. Both methods, simulated annealing and free MD simulations independently support S-configured α-hydroxy glycine thus enabling the assignment of all stereocenters in the structure of skyllamycin and devising the role of two-component flavin dependent monooxygenase (Sky39) as S-selective.