22107-31-9

Upstream product

• 563-41-7 semicarbazide hydrochloride 
• 99-93-4 4-Hydroxyacetophenone 
• 4426-72-6 hydrazine carboxamide 
• 108-95-2 phenol 
• 122-79-2 Phenyl acetate 

Downstream Products

• 879996-57-3 3-(4-hydroxyphenyl)-1H-pyrazole-4-carbaldehyde 
• 144305-95-3 Mn(C₆H₄(OH)C(CH₃)NNHC(O)NH₂)2Cl₂ 
• 59834-05-8 4-(4'-hydroxyphenyl)-1,2,3-thiadiazole 

Relevant academic research and scientific papers

Synthesis and antimicrobial activity of some novel [4-(1,2,3-thiadiazol-4-yl) phenoxy]methylene anchored 1,3,4-triazoles and 1,3,4-thiadiazoles

A series of novel [4-(1,2,3-thiadiazol-4-yl)phenoxy]methylene anchored 1,3,4-triazoles (8a-h) and 1,3,4-thiadiazoles (9a-i) were synthesized from thiosemicarbazide (7a-j). The structures of these newly synthesized compounds were confirmed on the basis of IR, 1H-NMR, mass spectral techniques, and elemental analysis. The in vitro antimicrobial screenings of the synthesized compounds were carried out against four bacterial pathogens, namely Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa and three fungal pathogens Candida albicans, Aspergillus niger and Aspergillus clavatus, using broth microdilution minimum inhibitory concentration method. The compounds 7d, 7j, 8a, 9a, 9b, and 9i exhibited promising antibacterial activity against the tested strains, whereas some compounds were found to be active against one of the tested bacterial strains.

Synthesis and biological evaluation of some pyrazole derivatives, containing (Thio) semicarbazide, as dual anti-inflammatory antimicrobial agents

Background: Several series of pyrazole derivatives containing (thio) semicarbazide (4a-4h, 5a-5l, 6a-6f, 7a-7c) were designed and synthesized to screen dual inflammatory and antimicrobial activities. Methods: The products were characterized by1

1,2,3-Selenadiazole-driven single family MSNCs of CdSe

Herein, 1,2,3-selenadiazoles were instantly prepared by hand grinding the reactants via a solventless process and tested for their ability to act as a source of selenium for the synthesis of CdSe magic-sized nanoclusters (MSNCs) with size below 2 nm. The

Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7

Necroptosis is a regulated caspase-independent cell death mechanism characterized by morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel potent small-molecule inhibitor of necroptosis, is structurally distinct from previously described necrostatins (Nec-1, Nec-3, Nec-4 and Nec-5). Here, we describe a series of structural modifications and the structure-activity relationship (SAR) of the Nec-7 series for inhibiting necroptosis.

Synthesis of 3-substituted arylpyrazole-4-carboxylic acids

A method was suggested for preparing previously unknown 3-aryl-substituted pyrazole-4-carboxylic acids, involving Vilsmeier formylation of semicarbazones of 26 available mono- and disubstituted acetophenones and 2-acetylthiophene followed by oxidation of