221072-58-8

Basic information

• Product Name: (2S)-benzyl 2-(1-hydroxyethyl)-1-pyrrolidinecarboxylate
• Synonyms: (2S)-benzyl 2-(1-hydroxyethyl)-1-pyrrolidinecarboxylate
• CAS NO: 221072-58-8
• Molecular Weight: 249.31
• Mol File: 221072-58-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S)-benzyl 2-(1-hydroxyethyl)-1-pyrrolidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-benzyl 2-(1-hydroxyethyl)-1-pyrrolidinecarboxylate(221072-58-8)
• EPA Substance Registry System: (2S)-benzyl 2-(1-hydroxyethyl)-1-pyrrolidinecarboxylate(221072-58-8)

Safety Data

• Hazardous Substances Data: 221072-58-8(Hazardous Substances Data)

Upstream product

• 75-16-1 methylmagnesium bromide 
• 71461-30-8 (S)-2-formylpyrrolidine-1-carboxylic acid benzyl ester 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 147-85-3 L-proline 
• 75315-63-8 N-(benzyloxycarbonyl)succinimide 
• 6216-63-3 N-Cbz-Prolinol 

Downstream Products

• 51207-70-6 (2S)-N-Benzyloxycarbony-2-(1'-methylethenyl)pyrrolidine 
• 221072-60-2 (4S)-ethyl 4-[1-[(benzyloxy)carbonyl]-2S-pyrrolidinyl]-4-hydroxypentanoate 
• 111491-98-6 (2S)-2-Acetyl-N-(benzyloxycarbonyl)pyrrolidine 

Relevant articles and documents

Unexpected diastereoselectivity in AD of an L-proline-derived 1,1- disubstituted alkene

Asymmetric dihydroxylation of the L-proline-derived 1,1-disubstituted alkene 5 catalysed by either (DHQ)2PHAL or (DHQD)2PHAL unexpectedly leads to preference for the same diastereomer 7, both reactions proceeding with apparently matching double diastereoselectivity. In contrast, AD using the analogous (DHQ)2PYR or (DHQD)2PYR ligands leads to preferences for diols 7 or 8 respectively.