22109-04-2Relevant academic research and scientific papers
Simple efficient routes for the preparation of pyrazoleamines and pyrazolopyrimidines: Regioselectivity of pyrazoleamines reactions with bidentate reagents
Moustafa, Moustafa Sherief,Al-Mousawi, Saleh Mohammed,Elnagdi, Mohamed Hilmy
, p. 71 - 79 (2016/07/15)
Simple and efficient routes for the preparation of 2-amino-5-phenyl-4, 5-dihydrofuran-3-carbonitrile (12), 2-oxo-5-phenyl-tetrahydrofuran-3-carbonitrile (13) and the 3, 5-diaminopyrazole derivative 2h were developed. The results of the reactivity profiles of 12 and 2h are reported and the previously investigated reaction of pyrazole-3, 5-diamine (2b) with acrylonitrile to yield compound (31), a N-1 acylation product, is currently justified by using X-ray crystallographic analysis. Taken together, the observation of alkenes and alkynes substitution when reacting with 3, 5-diaminopyrazole derivative 2h is explained by the terminal electron withdrawing group. This pattern of substitution is attributed to involvement of sterically unhindered electrophiles primarily at the N-1 position.
Polyfunction al nitriles in organic syntheses: A novel route to aminopyrroles, pyridazines and pyrazolo[3,4-c]pyridazines
Al-Mousawi, Saleh M.,Moustafa, Sherief,Meier, Herbert,Kolshorn, Heinz,Elnagdi, Mohamed Hilmy
experimental part, p. 798 - 806 (2009/05/27)
Phenacylmalononitrile 1 reacts with dimethylformamide dimethyl acetal to yield an enaminone which could be readily converted into a pyrrole or an aminopyridazine by treating with ammonium acetate and hydrazine hydrate, respectively. Compound 1 reacted wit
Reactivity of β,β-γ,γ-tetracyanoalkanones, β,β-dicyanoalkanones, and 5-amino-4-cyano-2,3-dihydrofurans
Nasakin,Sheverdov,Moiseeva,Ershov,Chernushkin,Tafeenko
, p. 291 - 300 (2007/10/03)
Procedures were developed for preparing polyfunctional alicyclic and heterocyclic compounds from tetracyanoalkanones, dicyanoalkanones, and 5-amino-4-cyano-2,3-dihydrofurans. From β,β,γ,γ-tetracyanoalkanones we prepared 5-amino-3a,4-dicyano-2,3,3a,6a-tetr
Studies on Heterocyclic Enaminonitriles. VI. Synthesis of 2-Amino-3-cyano-4,5-dihydrofurans
Matsuda, Takumi,Yamagata, Kenji,Tomioka, Yukihiko,Yamazaki, Motoyoshi
, p. 937 - 943 (2007/10/02)
Malononitrile reacts with 2-chloroethanol and 1-chloro-2-propanol (or 2-methyloxirane) in the presence of sodium ethoxide to give 2-amino-3-cyano-4,5-dihydrofuran (Ia) and 2-amino-3-cyano-5-methyl-4,5-dihydrofuran (Ib), respectively.The reaction of malono
