22109-04-2

Upstream product

• 14476-72-3 2-(2-oxo-2-phenylethyl)malononitrile 
• 96-09-3 styrene oxide 
• 109-77-3 malononitrile 
• 1674-30-2 1-phenyl-2-chloroethanol 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 486430-29-9 7a-ethoxy-2,3,3a,4,5,7a-hexahydro-6-methyl-2,4-diphenylfuro[2,3-b]pyridine-3a-carbonitrile 
• 216174-17-3 methyl 2-acetyl-4-cyanotetrahydro-3-imino-6-phenyl-2H-pyran-2-carboxylate 
• 216174-14-0 ethyl 2-acetyl-4-cyanotetrahydro-3-imino-6-phenyl-2H-pyran-2-carboxylate 
• 98061-62-2 2-benzamido-3-cyano-5-phenylfuran 
• 93013-70-8 5-phenyl-3-(2-phenylhydrazono)dihydrofuran-2-(3H)-one 
• 153929-26-1 3-ethyl-2-oxo-5-phenyl-3-pyrrolidinecarbonitrile 
• 203569-74-8 5,6-Diphenyl-2-(5-phenyl-2-piperidin-1-yl-4,5-dihydro-furan-3-yl)-[1,3]oxazin-4-one 
• 474095-31-3 2-amino-4,5-dihydro-5-phenyl-3-furancarboxamide 
• 486430-34-6 2,3,3a,4,5,7a-hexahydro-7a-methoxy-6-methyl-2,4-diphenylfuro[2,3-b]pyridine-3a-carbonitrile 

Relevant academic research and scientific papers

Simple efficient routes for the preparation of pyrazoleamines and pyrazolopyrimidines: Regioselectivity of pyrazoleamines reactions with bidentate reagents

Simple and efficient routes for the preparation of 2-amino-5-phenyl-4, 5-dihydrofuran-3-carbonitrile (12), 2-oxo-5-phenyl-tetrahydrofuran-3-carbonitrile (13) and the 3, 5-diaminopyrazole derivative 2h were developed. The results of the reactivity profiles of 12 and 2h are reported and the previously investigated reaction of pyrazole-3, 5-diamine (2b) with acrylonitrile to yield compound (31), a N-1 acylation product, is currently justified by using X-ray crystallographic analysis. Taken together, the observation of alkenes and alkynes substitution when reacting with 3, 5-diaminopyrazole derivative 2h is explained by the terminal electron withdrawing group. This pattern of substitution is attributed to involvement of sterically unhindered electrophiles primarily at the N-1 position.

Polyfunction al nitriles in organic syntheses: A novel route to aminopyrroles, pyridazines and pyrazolo[3,4-c]pyridazines

Phenacylmalononitrile 1 reacts with dimethylformamide dimethyl acetal to yield an enaminone which could be readily converted into a pyrrole or an aminopyridazine by treating with ammonium acetate and hydrazine hydrate, respectively. Compound 1 reacted wit

Reactivity of β,β-γ,γ-tetracyanoalkanones, β,β-dicyanoalkanones, and 5-amino-4-cyano-2,3-dihydrofurans

Procedures were developed for preparing polyfunctional alicyclic and heterocyclic compounds from tetracyanoalkanones, dicyanoalkanones, and 5-amino-4-cyano-2,3-dihydrofurans. From β,β,γ,γ-tetracyanoalkanones we prepared 5-amino-3a,4-dicyano-2,3,3a,6a-tetr

Studies on Heterocyclic Enaminonitriles. VI. Synthesis of 2-Amino-3-cyano-4,5-dihydrofurans

Malononitrile reacts with 2-chloroethanol and 1-chloro-2-propanol (or 2-methyloxirane) in the presence of sodium ethoxide to give 2-amino-3-cyano-4,5-dihydrofuran (Ia) and 2-amino-3-cyano-5-methyl-4,5-dihydrofuran (Ib), respectively.The reaction of malono