221112-37-4

Basic information

• Product Name: 3-amino-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one
• Synonyms: 3-amino-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one
• CAS NO: 221112-37-4
• Molecular Weight: 368.743
• Mol File: 221112-37-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-amino-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one(221112-37-4)
• EPA Substance Registry System: 3-amino-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one(221112-37-4)

Safety Data

• Hazardous Substances Data: 221112-37-4(Hazardous Substances Data)

Upstream product

• 141940-37-6 tert-butyl (4-(trifluoromethyl)phenyl)carbamate 
• 221113-30-0 N-[2-[(5-chloro-2-methoxyphenyl) carbonyl]-4-(trifluoromethyl) phenyl]aminocarboxylic acid, 1,1-dimethylethyl ester 
• 221113-33-3 N-[2-[(5-chloro-2-methoxyphenyl)carbonyl]-4-(trifluoromethyl)phenyl]chloroacetamide 
• 221113-32-2 (2-amino-5-trifluoromethyl-phenyl)-(5-chloro-2-methoxy-phenyl)-methanone 
• 33924-48-0 methyl 5-chloro-2-methoxybenzoate 

Downstream Products

• 474088-62-5 N-[4-(5-chloro-2-methoxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-yl]-C,C,C-trifluoro-methanesulfonamide 
• 221112-38-5 3-amino-4-(5-chloro-2-hydroxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one 
• 474088-65-8 N-[4-(5-chloro-2-methoxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-yl]-acetamide 
• 474088-64-7 N-[4-(5-chloro-2-methoxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-yl]-methanesulfonamide 

Relevant articles and documents

The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: A new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke.