221113-30-0

Basic information

• Product Name: Carbamic acid, [2-(5-chloro-2-methoxybenzoyl)-4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester
• CAS NO: 221113-30-0
• Molecular Formula: C20H19ClF3NO4
• Molecular Weight: 429.823
• Mol File: 221113-30-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-(5-chloro-2-methoxybenzoyl)-4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-(5-chloro-2-methoxybenzoyl)-4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester(221113-30-0)
• EPA Substance Registry System: Carbamic acid, [2-(5-chloro-2-methoxybenzoyl)-4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester(221113-30-0)

Safety Data

• Hazardous Substances Data: 221113-30-0(Hazardous Substances Data)

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 33924-48-0 methyl 5-chloro-2-methoxybenzoate 
• 141940-37-6 tert-butyl (4-(trifluoromethyl)phenyl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 221113-32-2 (2-amino-5-trifluoromethyl-phenyl)-(5-chloro-2-methoxy-phenyl)-methanone 
• 221113-33-3 N-[2-[(5-chloro-2-methoxyphenyl)carbonyl]-4-(trifluoromethyl)phenyl]chloroacetamide 
• 221112-38-5 3-amino-4-(5-chloro-2-hydroxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one 
• 221112-37-4 3-amino-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one 
• 474088-65-8 N-[4-(5-chloro-2-methoxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-yl]-acetamide 
• 474088-64-7 N-[4-(5-chloro-2-methoxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-yl]-methanesulfonamide 
• 474088-62-5 N-[4-(5-chloro-2-methoxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-yl]-C,C,C-trifluoro-methanesulfonamide 

Relevant articles and documents

The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: A new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke.

4-ARYL-3-AMINOQUINOLINE-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS

The present invention provides novel 4-aryl-3-aminoquinolin-2-one derivatives having the general formula STR1 wherein R, R 1, R. sup.2, R 3, R 4, R 5 and R 6 are as defined herein, or a non-toxic pharmaceutically acceptable salt thereof which are modulato