221113-33-3

Upstream product

• 79-04-9 chloroacetyl chloride 
• 221113-32-2 (2-amino-5-trifluoromethyl-phenyl)-(5-chloro-2-methoxy-phenyl)-methanone 
• 221113-30-0 N-[2-[(5-chloro-2-methoxyphenyl) carbonyl]-4-(trifluoromethyl) phenyl]aminocarboxylic acid, 1,1-dimethylethyl ester 
• 141940-37-6 tert-butyl (4-(trifluoromethyl)phenyl)carbamate 
• 33924-48-0 methyl 5-chloro-2-methoxybenzoate 

Downstream Products

• 474088-62-5 N-[4-(5-chloro-2-methoxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-yl]-C,C,C-trifluoro-methanesulfonamide 
• 474088-64-7 N-[4-(5-chloro-2-methoxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-yl]-methanesulfonamide 
• 474088-65-8 N-[4-(5-chloro-2-methoxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-yl]-acetamide 
• 221112-37-4 3-amino-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one 
• 221112-38-5 3-amino-4-(5-chloro-2-hydroxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one 

Relevant academic research and scientific papers

The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: A new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke.

4-ARYL-3-AMINOQUINOLINE-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS

The present invention provides novel 4-aryl-3-aminoquinolin-2-one derivatives having the general formula STR1 wherein R, R 1, R. sup.2, R 3, R 4, R 5 and R 6 are as defined herein, or a non-toxic pharmaceutically acceptable salt thereof which are modulato