221123-86-0Relevant academic research and scientific papers
Synthesis and evaluation of 4/5-hydroxy-2,3-diaryl(substituted)-cyclopent- 2-en-1-ones as cis-restricted analogues of combretastatin A-4 as novel anticancer agents
Gurjar, Mukund K.,Wakharkar, Radhika D.,Singh, Anu T.,Jaggi, Manu,Borate, Hanumant B.,Shinde, Popat D.,Verma, Ritu,Rajendran, Praveen,Dutt, Sarjana,Singh, Gurvinder,Sanna, Vinod K.,Singh, Manoj K.,Srivastava, Sanjay K.,Mahajan, Vishal A.,Jadhav, Vinod H.,Dutta, Kakali,Krishnan, Karthik,Chaudhary, Anika,Agarwal, Shiv K.,Mukherjee, Rama,Burman, Anand C.
, p. 1744 - 1753 (2008/02/02)
A new series of 2,3-diaryl-4/5-hydroxy-cyclopent-2-en-1-one analogues replacing the cis double bond of combretastatin A-4 (CA-4) by 4/5-hydroxy cyclopentenone moieties was designed and synthesized. The analogues displayed potent cytotoxic activity (ICsub
2-Diazoacetoacetic acid, an efficient and convenient reagent for the synthesis of α-diazo-β-ketoesters
Meyer, Michael E.,Ferreira, Eric M.,Stoltz, Brian M.
, p. 1316 - 1318 (2008/02/03)
The formation of various α-diazo acetoacetic esters can be obtained in a single transformation with good to excellent yields using readily available 2-diazoacetoacetic acid. The Royal Society of Chemistry 2006.
