221148-37-4

Basic information

• Product Name: 1-(2,2-Dibromo-vinyl)-3-fluoro-benzene
• Synonyms: 1-(2,2-Dibromo-vinyl)-3-fluoro-benzene
• CAS NO: 221148-37-4
• Molecular Weight: 279.934
• Mol File: 221148-37-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(2,2-Dibromo-vinyl)-3-fluoro-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2-Dibromo-vinyl)-3-fluoro-benzene(221148-37-4)
• EPA Substance Registry System: 1-(2,2-Dibromo-vinyl)-3-fluoro-benzene(221148-37-4)

Safety Data

• Hazardous Substances Data: 221148-37-4(Hazardous Substances Data)

Upstream product

• 558-13-4 carbon tetrabromide 
• 456-48-4 3-Fluorobenzaldehyde 

Downstream Products

• 115665-64-0 2-Brom-1-(3-fluor-phenyl)-ethylen 
• 852818-41-8 C₁₂H₈FN₃O 
• 221148-50-1 6-difluoromethoxy-2-(3-fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine 
• 2561-17-3 1-ethynyl-3-fluoro-benzene 
• 115665-70-8 (E)-1-(2-bromovinyl)-3-fluorobenzene 
• 1344717-54-9 (E)-9-benzyl-6-(benzylthio)-8-(3-fluorostyryl)-9H-purine 
• 221148-38-5 methyl 3-(3-fluorophenyl)prop-2-ynoate 
• 1006585-20-1 1,4-bis(3-fluorophenyl)buta-1,3-diyne 
• 1616878-01-3 3-((3-fluorophenyl)ethynyl)indolizine-1-carbonitrile 
• 58686-65-0 ethyl 3-(3-fluorophenyl)propiolate 
• 813414-83-4 1-bromo-2-(meta-fluorophenyl)ethyne 

Relevant articles and documents

Direct Alkynylation of 3H-Imidazo[4,5-b]pyridines Using gem-Dibromoalkenes as Alkynes Source

C2 direct alkynylation of 3H-imidazo[4,5-b]pyridine derivatives is explored for the first time. Stable and readily available 1,1-dibromo-1-alkenes, electrophilic alkyne precursors, are used as coupling partners. The simple reaction conditions include an inexpensive copper catalyst (CuBr·SMe2 or Cu(OAc)2), a phosphine ligand (DPEphos) and a base (LiOtBu) in 1,4-dioxane at 120 °C. This C-H alkynylation method revealed to be compatible with a variety of substitutions on both coupling partners: heteroarenes and gem-dibromoalkenes. This protocol allows the straightforward synthesis of various 2-alkynyl-3H-imidazo[4,5-b]pyridines, a valuable scaffold in drug design.

Rh-Catalyzed Asymmetric Hydrogenation of β-Substituted-β-thio-α,β-unsaturated Esters: Expeditious Access to Chiral Organic Sulfides

Rh/bifunctional bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydorgenation of both (Z)- and (E)-isomers of β-substituted-β-thio-α,β-unsaturated esters was successfully developed. This new asymmetric catalytic methodology provided highly efficient access to two enantiomers of chiral organic sulfides ethyl β-substituted-β-thio-propanoates with excellent results (up to 99% yield and >99% ee for (Z)-substrates, up to 99% yield and 98% ee for (E)-substrates, TON up to 5000), which are important intermediates in organic synthesis.

USE OF CYCLOOXYGENASE-2 INHIBITORS FOR THE TREATMENT OF DEPRESSIVE DISORDERS

The invention concerns the use of compounds of formula (I), (II) and (III): which are COX-2 (cyclooxygenase-2) inhibitors, and pharmaceutically acceptable salts or solvates thereof, for the treatment of depressive disorders in combination with an effective amount of a second component which is a selective serotonin reuptake inhibitor.