221148-38-5

Basic information

• Product Name: (3-Fluoro-phenyl)-propynoic acid methyl ester
• Synonyms: (3-Fluoro-phenyl)-propynoic acid methyl ester;methyl 3-(3-fluorophenyl)propiolate
• CAS NO: 221148-38-5
• Molecular Formula: C₁₀H₇FO₂
• Molecular Weight: 178.1597832
• Mol File: 221148-38-5.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3-Fluoro-phenyl)-propynoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3-Fluoro-phenyl)-propynoic acid methyl ester(221148-38-5)
• EPA Substance Registry System: (3-Fluoro-phenyl)-propynoic acid methyl ester(221148-38-5)

Safety Data

• Hazardous Substances Data: 221148-38-5(Hazardous Substances Data)

Usage

General Description

"(3-Fluoro-phenyl)-propynoic acid methyl ester" is a chemical compound with the molecular formula C10H7FO2. It is a methyl ester derivative of propynoic acid, which contains a fluorine-substituted phenyl group. (3-Fluoro-phenyl)-propynoic acid methyl ester is commonly used in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is also utilized as a building block in organic chemical reactions and as a reagent in the production of other chemical compounds. The presence of the fluorine group in the phenyl ring makes this compound potentially valuable for its unique reactivity and physical properties, which can be further exploited in various applications in the chemical and pharmaceutical industries.

Upstream product

• 2561-17-3 1-ethynyl-3-fluoro-benzene 
• 79-22-1 methyl chloroformate 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 922-67-8 propynoic acid methyl ester 
• 74-88-4 methyl iodide 
• 558-13-4 carbon tetrabromide 
• 456-48-4 3-Fluorobenzaldehyde 
• 221148-37-4 1-(2,2-Dibromo-vinyl)-3-fluoro-benzene 
• 1711-07-5 3-fluorobenzoyl chloride 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 221148-39-6 2-(3-fluoro-phenyl)-6-methoxy-pyrazolo[1,5-b]pyridazine-3-carboxylic acid methyl ester 
• 267235-92-7 2-(3-fluoro-phenyl)-6-trifluoromethyl-pyrazolo[1,5-a]pyridine-3-carboxylic acid methyl ester 
• 781674-54-2 2-(3-fluoro-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid 
• 852818-41-8 C₁₂H₈FN₃O 
• 221148-50-1 6-difluoromethoxy-2-(3-fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine 
• 221148-43-2 3-bromo-6-difluoromethoxy-2-(3-fluoro-phenyl)-pyrazolo[1,5-b]pyridazine 
• 221148-40-9 2-(3-fluoro-phenyl)-6-methoxy-pyrazolo[1,5-b]pyridazine-3-carboxylic acid 
• 221148-41-0 3-bromo-2-(3-fluoro-phenyl)-6-methoxy-pyrazolo[1,5-b]pyridazine 

Relevant articles and documents

Asymmetric Transfer Hydrogenation of gem-Difluorocyclopropenyl Esters: Access to Enantioenriched gem-Difluorocyclopropanes

Catalytic enantioselective access to disubstituted functionalized gem-difluorocyclopropanes, which are emerging fluorinated motifs of interest in medicinal chemistry, was achieved through asymmetric transfer hydrogenation of gem-difluorocyclopropenyl este

Salt-Free Strategy for the Insertion of CO2 into C?H Bonds: Catalytic Hydroxymethylation of Alkynes

A copper(I) catalyst enables the insertion of carbon dioxide into alkyne C?H bonds by using a suitable organic base with which hydrogenation of the resulting carboxylate salt with regeneration of the base becomes thermodynamically feasible. In the presence of catalytic copper(I) chloride/4,7-diphenyl-1,10-phenanthroline, polymer-bound triphenylphosphine, and 2,2,6,6-tetramethylpiperidine as the base, terminal alkynes undergo carboxylation at 15 bar CO2 and room temperature. After filtration, the ammonium alkynecarboxylate can be hydrogenated to the primary alcohol and water at a rhodium/molybdenum catalyst, regenerating the amine base. This demonstrates the feasibility of a salt-free overall process, in which carbon dioxide serves as a C1 building block in a C?H functionalization.

Palladium-Catalyzed Ylidyl-Carbonylation of Aryl Halides to Produce α-Acylphosphoranes

An efficient synthesis of α-acylphosphoranes by palladium-catalyzed carbonylation of aryl iodides with carbon monoxide and stabilized phosphonium ylides has been developed. Featuring 44 examples, the protocol displayed a wide substrate scope under mild reaction conditions, showcasing its potential in synthetic organic chemistry.