221174-14-7Relevant academic research and scientific papers
HOAt.DCHA as co-coupling agent in the synthesis of peptides employing Fmoc-amino acid chlorides as coupling agents: Application to the synthesis of ss-casomorphin
Sureshbabu, Vommina V.,Chennakrishnareddy, Gundala
experimental part, p. 981 - 988 (2009/12/28)
A simple, efficient and racemization free method for the synthesis of peptides employing Fmoc-amino acid chlorides mediated by HOAtDCHA as a co-coupling agent has been described. This protocol is successfully employed in the synthesis of the pentapeptide H-Pro-Gly-VaI-GIy-VaI-OH (PGVGV), and ss-casomorphin (H-Tyr-Pro-Phe-Pro-Gly-OH) in 85 and 80% yields, respectively.
Microwave accelerated high speed solution synthesis of peptides employing HATU/HOAt
Sudarshan, Naremaddepalli S.,Suresh Babu, Vommina V.
, p. 1509 - 1511 (2007/10/03)
The chemical synthesis of peptides employing HATU/HOAt as a coupling agent under microwave irradiation has been described. The couplings found to be complete in 30-40 s. The yield as well as purity of the peptides made is found to be good. All the peptide
Fmoc-peptide acid chlorides in fragment coupling: Synthesis of β- casomorphin by 3+2 divergent approach
Suresh Babu,Gayathri,Gopi
, p. 79 - 91 (2007/10/03)
Fmoc-peptide acid chlorides are prepared and used as rapid and efficient coupling agents in fragment coupling. Thus the synthesis of the model tetrapeptide Leu-Ala-Gly-Val and β-casomorhin (Tyr-Pro-Phe-Pro-Gly) are accomplished by the (2+2) and (3+2) divergent approach respectively.
Synthesis of peptides mediated by AgCN
Suresh Babu,Gayathri
, p. 1109 - 1113 (2007/10/03)
The acylation reactions employing Fmoc-amino acid chlorides have been carried out in the presence of AgCN. There is no addition of any base. The coupling is fast and racemization free. The work up and the isolation of products are easy. Thus the synthesis of several dipeptides, a model tetrapeptide, Leu-Ala-Gly-Val and β-casomorphin (Tyr-Pro-Phe-Pro-Gly) are accomplished.
