221177-67-9

Usage

Uses

Used in Pharmaceutical Research:
(7-(Benzyloxy)benzo[d][1,3]dioxol-5-yl)methanol is used as a building block in pharmaceutical research for its potential in developing new drugs and bioactive molecules. Its unique structure and functional groups contribute to its versatility in creating a wide range of complex organic compounds, which can be tailored for specific therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, (7-(Benzyloxy)benzo[d][1,3]dioxol-5-yl)methanol is used as a key intermediate for constructing various complex organic compounds. Its benzyl group's ease of removal or modification allows for further customization of the synthesized products, making it a preferred choice for researchers looking to create novel chemical entities with specific properties and functions.
Used in Medicinal Chemistry:
(7-(Benzyloxy)benzo[d][1,3]dioxol-5-yl)methanol is utilized in medicinal chemistry as a valuable compound for the discovery and development of new drugs. Its structural features and the ability to modify its benzyl group make it an ideal candidate for creating molecules with targeted biological activities, potentially leading to the creation of more effective and safer pharmaceuticals.

Upstream product

• 142531-43-9 methyl 7-(benzyloxy)benzo[d][1,3]dioxole-5-carboxylate 
• 99-24-1 methyl galloate 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 116119-01-8 methyl 7-hydroxybenzo[d][1,3]dioxole-5-carboxylate 
• 79831-86-0 methyl 3-(benzyloxy)-4,5-dihydroxybenzoate 

Downstream Products

• 221177-68-0 7-(benzyloxy)benzo[d][1,3]dioxole-5-carbaldehyde 
• 944729-84-4 4-(benzyloxy)-6-(chloromethyl)benzo[d][1,3]dioxole 
• 1618102-15-0 C₂₆H₂₆O₈ 
• 221177-65-7 2-(5-methoxy-2,3-methylendioxyphenoxy)phenylacetic acid 
• 221177-71-5 2-(5-methoxy-2,3-methylendioxyphenoxy)benzoic acid 
• 221177-74-8 2-(5-methoxy-2,3-methylendioxyphenoxy)benzyl cyanide 
• 221177-72-6 2-(5-methoxy-2,3-methylendioxyphenoxy)benzyl alcohol 
• 221177-73-7 2-(5-methoxy-2,3-methylendioxyphenoxy)benzyl bromide 
• 221177-70-4 1-benzyloxy-5-methoxy-2,3-methylendioxybenzene 
• 221177-69-1 4-benzyloxy-6-hydroxy-1,3-benzodioxole 
• 132922-67-9 6-(3-hydroxyphenylethyl)benzo[d][1,3]dioxol-4-ol 
• 944730-06-7 (E)-4-(2-(7-(benzyloxy)benzo[d][1,3]dioxol-5-yl)vinyl)-N,N-dimethylbenzenamine 
• 944730-05-6 (E)-4-(benzyloxy)-6-(4-methoxystyryl)benzo[d][1,3]dioxole 
• 944730-04-5 (E)-4-(benzyloxy)-6-(4-fluorostyryl)benzo[d][1,3]dioxole 

Relevant academic research and scientific papers

Synthesis and cytotoxicity evaluation of a novel justicidin G analogue and its phosphate ester

The novel justicidin G analogue 13 and its phosphate ester 15 were synthesized as potential anticancer agents in several steps starting from commercially available methyl gallate and veratraldehyde. The cytotoxicity of the intermediates was tested against HCT-8, BEL-7402, KETR3, HELA, BGC-823, KB and MCF-7 cell lines by the MTT test, and compound 15 exhibited significant cytotoxicity in HELA and KB cell lines.

Synthesis and anti-proliterative in-vitro activity of two natural dihydrostilbenes and their analogues

A total synthetic route for two natural dihydrostilbenes with significant cytotoxicity toward human cancer cell lines, (3-(2-(7-methoxybenzo[d][1,3] dioxol-5-yl)ethyl)phenol 1a and 6-(3-hydroxyphenethyl)benzo[d][1,3]dioxol-4-ol 1b), which were isolated from Bulbophyllum odoratissimum Lind1, was developed via Wittig-Horner reaction. The natural products 1a and 1b were obtained in 28% and 20% overall yield, respectively. Additionally, nine analogues, 1c-1k, of the two natural dihydrostilbenes were synthesized and evaluated for their anti-proliferative activity against human SGC-7901, KB and HT-1080 cell lines by MTT assay. The activities of 1c and 1d were in the same range as those of the natural products 1a and 1b.

Synthesis of an antioxidant having a dibenz[b,f]oxepine skeleton

Dibenz[b,f]oxepine derivative (1) isolated from a yeast as an antioxidant was synthesized via 17 reaction steps starting from methyl gallate. However, the physicochemical data of the synthetic compound (1) were different from the previously reported values. Moreover, the antioxidative activity of the synthetic 1 was slightly more active than that of the natural product.