221203-07-2Relevant academic research and scientific papers
Parallel synthesis of 2-alkoxy and 2-acyloxyphenylpropyl amides and amines using dihydrocoumarins as versatile synthons. Application of a novel resin quench-capture method
Bussolari,Rehborn,Combs
, p. 1241 - 1244 (1999)
A solution phase synthesis for the preparation of libraries of 2- substituted phenylpropyl amines and amides was accomplished using dihydrocoumarins as a useful synthon in parallel synthesis. Resin quench methods were utilized in the purifications of the amides and a resin quench- capture method was utilized in metallo-organic reductions leading to the targeted phenylpropyl amines.
