Parallel synthesis of 2-alkoxy and 2-acyloxyphenylpropyl amides and amines using dihydrocoumarins as versatile synthons. Application of a novel resin quench-capture method

Article abstract of DOI:10.1016/S0040-4039(98)02598-2

A solution phase synthesis for the preparation of libraries of 2- substituted phenylpropyl amines and amides was accomplished using dihydrocoumarins as a useful synthon in parallel synthesis. Resin quench methods were utilized in the purifications of the amides and a resin quench- capture method was utilized in metallo-organic reductions leading to the targeted phenylpropyl amines.