22121-91-1

Upstream product

• 13676-06-7 ethyl 2-ethoxy-2-(diethylphosphono)acetate 
• 100-52-7 benzaldehyde 
• 591-50-4 iodobenzene 
• 22121-86-4 ethyl 2-ethoxyacrylate 
• 6065-82-3 Ethyl diethoxyacetate 

Downstream Products

• 103986-74-9 (Z)-2-ethoxy-3-phenylacrylic acid 
• 719293-70-6 3-(4-chlorosulfonyl-phenyl)-2-ethoxypropionic acid ethyl ester 
• 719293-65-9 2-ethoxy-3-(4-mercapto-phenyl)-propionic acid methyl ester 
• 719293-23-9 2-ethoxy-3-[4-(2-{[6-({2-[4-(2-ethoxy-2-methoxycarbonyl-ethyl)-phenylsulfanyl]-ethyl}-methyl-amino)-pyridin-2-yl]-methyl-amino}-ethylsulfanyl)-phenyl]-propionic acid methyl ester 
• 719293-24-0 3-[4-(2-{[6-({2-[4-(2-Carboxy-2-ethoxy-ethyl)-phenylsulfanyl]-ethyl}-methyl-amino)-pyridin-2-yl]-methyl-amino}-ethylsulfanyl)-phenyl]-2-ethoxy-propionic acid 
• 719293-69-3 ethyl 2-ethoxy-3-phenylpropionate 
• 156-06-9 2-oxo-3-(phenyl)propionic acid 

Relevant academic research and scientific papers

DICARBOXYLIC ACID DERIVATIVES AS PPAR-AGONISTS

A novel class of dicarboxylic acid derivatives, the use of these compounds as phar-maceutical compositions, pharmaceutical compositions comprising the compounds and meth-ods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Prolifera-tor-Activated Receptors (PPAR).

PALLADIUM-CATALYZED CROSS-COUPLING OF ARYL IODIDES WITH ETHYL 2-ETHOXY- AND 3-ETHOXYACRYLATE

The cross-coupling of iodobenzenes with ethyl 2-ethoxy- and 3-ethoxyacrylate in the presence of palladium-charcoal gave ethyl α-ethoxy- and β-ethoxycinnamates in moderate yields.The cross-coupling of N-heteroaryl iodides with the same acrylates was also d