221218-66-2

Basic information

• Product Name: N-(3-ACETYLTHIOPROPYL)PHTHALIMIDE 97
• Synonyms: N-(3-ACETYLTHIOPROPYL)PHTHALIMIDE 97
• CAS NO: 221218-66-2
• Molecular Formula: C13H13NO3S
• Molecular Weight: 263.316
• Product Categories: Organic Building Blocks;Protected Thiols/Mercaptans;Sulfur Compounds
• Mol File: 221218-66-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 90-94 °C(lit.)
• Boiling Point: 406.1ºC at 760 mmHg
• Flash Point: 199.4ºC
• Appearance: /
• Density: 1.311g/cm3
• Vapor Pressure: 8.36E-07mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: N-(3-ACETYLTHIOPROPYL)PHTHALIMIDE 97(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-ACETYLTHIOPROPYL)PHTHALIMIDE 97(221218-66-2)
• EPA Substance Registry System: N-(3-ACETYLTHIOPROPYL)PHTHALIMIDE 97(221218-66-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 221218-66-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H13NO3S/c1-9(15)18-8-4-7-14-12(16)10-5-2-3-6-11(10)13(14)17/h2-3,5-6H,4,7-8H2,1H3

Upstream product

• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 10387-40-3 potassium thioacetate 
• 5428-09-1 3-phthalimido-1-propene 
• 507-09-5 tiolacetic acid 
• 42251-84-3 N-(3-chloropropyl)phthalimide 
• 85-44-9 phthalic anhydride 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 52096-83-0 2-<3-(Benzylthio)propyl>-1H-isoindole-1,3(2H)-dione 
• 39801-32-6 2-(3-mercaptopropyl)isoindoline-1,3-dione 

Relevant articles and documents

Squaryl group modified phosphoglycolipid analogs as potential modulators of GPR55

Lysophosphatidyl glucoside (LPGlc) is a structurally unique glycolipid that acts as a guidance cue for extending axons during central nervous system development by activating the class A G protein coupled receptor (GPR) 55 of spinal cord sensory axons. GPR55 not only plays an important role during development, but is also implicated in many disease states, rendering molecules that target GPR55 of widespread interest. In this study, we developed synthetic access to a novel class of LPGlc analogues featuring a squaryl diamide group as surrogate for the phosphodiester. We report the facile synthesis of a series of LPGlc analogues, their GPR dependent biological activity and a systematic analysis of the structure-activity relationship in regards to GPR55 modulation. The lead compound featuring identical configuration at all stereocenters compared to natural LPGlc exhibits an activity to repel axons of dorsal root ganglion (DGR) nociceptive neurons.

Visible-Light-Mediated Organocatalyzed Thiol-Ene Reaction Initiated by a Proton-Coupled Electron Transfer

A convenient method for performing a thiol-ene reaction is described. The reaction is performed under blue-light irradiation and catalyzed by photoactive Lewis basic molecules such as acridine orange or naphthalene-fused N-acylbenzimidazole. It is believed that the process is initiated by a proton-coupled electron transfer process within the complex between the thiol and the Lewis basic catalyst.

Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents

A series of sulforaphane derivatives were synthesized and evaluated in vitro for their cytotoxicity against five cancer cell lines (HepG2, A549, MCF-7, HCT-116 and SH-SY5Y). The pharmacological results showed that many of the derivatives displayed more potent cytotoxicity than sulforaphane (SFN). Furthermore, SFN and derivative 85 could induce cell cycle arrest at S or G2/M phase and cell apoptosis. SFN and 85 exhibited time- and dose-dependent activation on Nrf2 transcription factor, and 85 acted as a more potent Nrf2 inducer than SFN.