22125-33-3Relevant academic research and scientific papers
Diphenylcyclopropyl analogs
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, (2008/06/13)
Diphenylcyclopropyl analogs in which one or more of the phenyl rings includes alkoxy substituents including a dialkylaminoalkoxy group, an unsubstituted piperazine alkoxy group, a substituted piperazine alkoxy group, an unsubstituted piperidine alkoxy group, and a substituted piperidine alkoxy group, and which may have one or two alkyl groups bonded to the cyclopropane. The compounds are useful as antiestrogens and anti-tumor agents.
Gem-dichlorocyclopropanes as antitumor agents
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, (2008/06/13)
Gem-Dichlorocyclopropanes (Analog II derivatives) which demonstrate antiproliferative activity toward MCF-7 cells, in vitro and are generally not reversed by estradiol or having intrinsic estrogenicity (except the hydroxyphenyl derivative Compound 30). In general the cyclopropane compounds have the formula: STR1 or any pharmaceutically acceptable salt thereof. X is selected from a group consisting of hydrogen and halogen atoms. The group R1 may be a hydrogen atom, an alkyl group, an acyl group, or an arylalkyl group. The group R2 may be a hydrogen atom, an unsubstituted aryl group or a substituted aryl group. The group R3 may be a hydrogen atom, an alkyl group, a cycloalkyl group, a substituted aryl group or an unsubstituted aryl group. The group R4 may be a hydrogen atom, an unsubstituted aryl group or a substituted aryl group. The R4 is absent when R3 is a cycloalkyl group having a first position carbon and a terminal position carbon bonded to the same carbon of the cyclopropane. Further, no more than any two of R2, R3 and R4 has an aryl group.
Cyclopropyl analogs as anti-estrogenic, anti-tumor and female fertility agents
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, (2008/06/13)
Anti-estrogenic cyclopropyl analogs such as 1,1-dichlorocis-2,3-diphenylcyclopropane, when administered to a subject function as anti-tumor agents to prevent the development of estrogen-dependent tumors in the subject and substantially arrest the growth and metastatic involvement of existing estrogen-dependent tumors in the subject. Further, the anti-estrogenic cyclopropyl analogs may be used as anti-estrogenic agents and as fertility agents in the treatment of female infertility. The cyclopropyl analogs useful as anti-tumor, anti-estrogenic and female fertility agents have the general structure wherein: X is a halogen or hydrogen atom; R1 is a hydrogen atom, an alkyl group containing from 1 to about 3 carbon atoms, a monocyclic group, a hydroxy substituted monocyclic group, an alkoxy substituted monocyclic group in which the alkyl substituent contains from 1 to about 3 carbon atoms or an acetoxy substituted monocyclic group; R2 is a hydrogen atom, an acetate group, a hydroxyl group, an alkoxy group in which the alkyl substituent contains from 1 to about 3 carbon atoms, a beta-dialkylaminoethoxy group wherein the alkyl substituent contains from 1 to about 6 carbon atoms, a beta-monoaminoheterocycloethoxy group, or pharmaceutically acceptable salts thereof; R3 is a hydrogen atom, an acetate group, a hydroxyl group, or an alkoxy group in which the alkyl substituent contains from 1 to about 3 carbon atoms; R4 is a hydrogen atom, or an alkyl group containing from 1 to about 3 carbon atoms; and the wavy lines ( ) in the structure indicate that the anti-tumor agent can be the cis- or trans-isomers.
Arylcyclopropane Photochemistry. Effects of Electron-Donating and Electron-Withdrawing Aromatic Substituents on the Photochemical Rearrangements of 1,1-Diarylcyclopropanes.
Hixson, Stephen S.,Franke, Lothar A.
, p. 2706 - 2711 (2007/10/02)
Irradiation of 1,1-diarylcyclopropanes 4a-g, having substituents X and Y at the para positions of the aromatic rings, afforded 1,1-diarylpropenes 5a-g and 1-arylindans 6a-f.The rate constants of these (singlet state) reactions, determined from the reactan
Substituted cyclopropanes
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, (2008/06/13)
1,1-Di(p-substituted phenyl)-2,2-dichlorocyclopropanes, wherein the phenyl substituted are alkyl or alkoxy, as new compounds insecticides.
