221284-07-7

Basic information

• Product Name: 1-tert-butoxycarbonyl-2-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-indole
• Synonyms: 1-tert-butoxycarbonyl-2-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-indole
• CAS NO: 221284-07-7
• Molecular Weight: 557.533
• Mol File: 221284-07-7.mol

Chemical Properties

• CAS DataBase Reference: 1-tert-butoxycarbonyl-2-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-butoxycarbonyl-2-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-indole(221284-07-7)
• EPA Substance Registry System: 1-tert-butoxycarbonyl-2-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-indole(221284-07-7)

Safety Data

• Hazardous Substances Data: 221284-07-7(Hazardous Substances Data)

Upstream product

• 73852-19-4 3,5-bis-trifluromethylphenylboronic acid 
• 221283-98-3 1-tert-butoxycarbonyl-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-indole 
• 221283-99-4 1-tert-butoxycarbonyl-2-bromo-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-indole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 156049-44-4 3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-indole 

Downstream Products

• 221284-10-2 1-tert-Butoxycarbonyl-2-[3,5-bis(trifluoromethyl)phenyl]-3-(2-hydroxyethyl)-1H-indole 

Relevant articles and documents

2-aryl tryptamines: Selective high-affinity antagonists for the h5-HT(2A) receptor

A series of 2-aryl tryptamines have been identified as high-affinity h5-HT(2A) antagonists. Structure-activity relationship studies have shown that h5-HT(2A) affinity can be attained via modifications to the tryptamine side chain and that selectivity over h5-HT(2C) and hD2 receptors can be controlled by suitable C-2 aryl groups. (C) 2000 Elsevier Science Ltd.

Phenylindole derivatives as 5-HT2A receptor ligands

A class of tryptamine analogues bearing an optionally substituted phenyl nucleus at the 2-position are selective antagonists of the human 5-HT2Areceptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or preve