221284-10-2

Upstream product

• 221283-99-4 1-tert-butoxycarbonyl-2-bromo-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-indole 
• 73852-19-4 3,5-bis-trifluromethylphenylboronic acid 
• 156049-44-4 3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-indole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 221283-98-3 1-tert-butoxycarbonyl-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-indole 
• 221284-07-7 1-tert-butoxycarbonyl-2-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-1H-indole 

Downstream Products

• 221282-94-6 2-[3,5-Bis(trifluoromethyl)phenyl]-3-[2-(N-methyl-N-isopropylamino)ethyl]-1H-indole 

Relevant academic research and scientific papers

Phenylindole derivatives as 5-HT2A receptor ligands

A class of tryptamine analogues bearing an optionally substituted phenyl nucleus at the 2-position are selective antagonists of the human 5-HT2Areceptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or preve

2-aryl tryptamines: Selective high-affinity antagonists for the h5-HT(2A) receptor

A series of 2-aryl tryptamines have been identified as high-affinity h5-HT(2A) antagonists. Structure-activity relationship studies have shown that h5-HT(2A) affinity can be attained via modifications to the tryptamine side chain and that selectivity over h5-HT(2C) and hD2 receptors can be controlled by suitable C-2 aryl groups. (C) 2000 Elsevier Science Ltd.