22130-02-5Relevant academic research and scientific papers
3-Aminocarbazole Compounds, Pharmaceutical Composition Containing the Same and Method for the Preparation Thereof
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Page/Page column 4, (2008/12/08)
A compound of formula (I), in which R1, R2, R3, R4, R5, R6, X and Y have the meanings indicated in the description, and the pharmaceutically acceptable salts thereof. A pharmaceutical composition containing a compound of formula (I) or a pharmaceutically acceptable salt thereof. A method for preparing the abovementioned compound of formula (I) and the pharmaceutically acceptable salts thereof.
3-AMINOCARBAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND METHOD FOR THE PREPARATION THEREOF
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Page/Page column 13, (2010/11/25)
A compound of formula (I), in which R1 , R2, R3, R4, R5, R6, X and Y have the meanings indicated in the description, and the pharmaceutically acceptable salts thereof. A pharmaceutical composition containing a compound of formula (I) or a pharmaceutically acceptable salt thereof. A method for preparing the abovementioned compound of formula (I) and the pharmaceutically acceptable salts thereof.
Structure-activity relationships in a series of NPY Y5 antagonists: 3-Amido-9-ethylcarbazoles, core-modified analogues and amide isosteres
Hammond, Marlys,Elliott, Richard L.,Gillaspy, Melissa L.,Hager, David C.,Hank, Richard F.,LaFlamme, Janet A.,Oliver, Robert M.,DaSilva-Jardine, Paul A.,Stevenson, Ralph W.,Mack, Christine M.,Cassella, James V.
, p. 1989 - 1992 (2007/10/03)
Beginning with carbazole 1a, the amide and alkyl substituents were optimized to maintain potency while adding solubilizing groups. Efforts to replace the 3-amino-9-ethylcarbazole core, a known carcinogen, used the SAR generated in the carbazole series for guidance and led to the synthesis of a number of core-modified analogues. In addition, an isosteric series, in which the amide was replaced with an imidazole, was prepared. Two potent new series lacking the putative toxicophore were identified from these endeavors.
Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity
Block, Michael H.,Boyer, Scott,Brailsford, Wayne,Brittain, David R.,Carroll, Debra,Chapman, Steve,Clarke, David S.,Donald, Craig S.,Foote, Kevin M.,Godfrey, Linda,Ladner, Anthony,Marsham, Peter R.,Masters, David J.,Mee, Christine D.,O'Donovan, Michael R.,Pease, J. Elizabeth,Pickup, Adrian G.,Rayner, John W.,Roberts, Andrew,Schofield, Paul,Suleman, Abid,Turnbull, Andrew V.
, p. 3509 - 3523 (2007/10/03)
The hypothesis that antagonists of the neuropeptide Y5 receptor would provide safe and effective appetite suppressants for the treatment of obesity has prompted vigorous research to identify suitable compounds. We discovered a series of acylated aminocarb
Carbazole neuropeptide Y5 antagonists
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, (2008/06/13)
Carbazoles of the formula which are effective in treating conditions associated with neuropeptide Y-5 neurotransmission.
A new method of nitration of carbazoles using ceric ammonium nitrate (CAN)
Chakrabarty,Batabyal
, p. 1 - 10 (2007/10/02)
A convenient procedure for the mononitration of carbazole and 9-alkylcarbazoles using CAN in CH3CN in presence of SiO2 is reported. The results with 9-acetyl, 9-benzoyl and 9- benzenesulphonylcarbazoles are also discussed.
