221346-31-2Relevant academic research and scientific papers
Efficient and selective deuteration of phenylalanine derivatives catalyzed by Pd/C
Maegawa, Tomohiro,Akashi, Akira,Esaki, Hiroyoshi,Aoki, Fumiyo,Sajiki, Hironao,Hirota, Kosaku
, p. 845 - 847 (2005)
A facile and efficient deuteration method of phenylalanine derivatives using a Pd/C-H2-D2O system has been developed. Selective deuteration at the β-position of phenylalanine derivatives occurred using Pd/C as a catalyst with high deuterium efficiency without racemization at 110°C. Also, the α-position was deuterated at higher temperature.
Preparation of Deuterium Labeled Compounds by Pd/C-Al-D2O Facilitated Selective H-D Exchange Reactions
Kadish, Dora,Kokel, Anne,T?r?k, Béla
supporting information, (2022/01/24)
The chemo/regioselective H-D exchange of amino acids and synthetic building blocks by an environmentally benign Pd/C-Al-D2O catalytic system is described. Due to the importance of isotope labeled compounds in medicinal chemistry and structural biology, no
