22147-17-7Relevant academic research and scientific papers
Aliphatic vs. aromatic C-H bond activation of phenylcyclohexane catalysed by cytochrome P450cam
England, Paul A.,Rouch, Duncan A.,Westlake, Andrew C. G.,Bell, Stephen G.,Nickerson, Darren P.,Webberley, Matthew,Flitsch, Sabine L.,Wong, Luet-Lok
, p. 357 - 358 (1996)
Catalytic hydroxylation of phenylcyclohexane 1 by wild-type and the Y96A and Y96F mutant forms of cytochrome P450cam occurs only at the 3- and 4-positions on the cyclohexane ring, giving cis-3-phenylcyclohexanol 2, cis-4-phenylcyclohexanol 3 and trans-4-phenylcyclohexanol 4.
A new paradigm for biohydroxylation by Beauveria bassiana ATCC 7159
Holland, Herbert L.,Morris, Terence A.,Nava, Phillip J.,Zabic, Mirjana
, p. 7441 - 7460 (2007/10/03)
The biohydroxylation of a series of amides and related amino, keto and hydrocarbon substrates by the fungal biocatalyst Beauveria bassiana ATCC 7159 has been examined. The product distributions, together with data obtained from selective inhibition experiments using the cyt.P-450 inhibitors isosafrole, 1-aminobenzotriazole and phenylacetylene, suggest that B. bassiana contains a range of hydroxylase enzymes with different substrate specificities. A paradigm is presented for the interpretation of the results of microbial hydroxylation and for the application of existing active site models for B. bassiana.
Lipase-mediated diastereoselective and enantioselective acetylations of 3-substituted cyclohexanols
Tanikaga, Rikuhei,Morita, Akira
, p. 635 - 638 (2007/10/03)
Lipase-mediated acetylation of four diastereomeric and enantiomeric isomers of 3-substituted cyclohexanols 2 has led to an efficient resolution to provide a single stereoisomer, (1R,3S)-cyclohexyl acetate (1R,3S)-3 in a high enantiomeric excess.
Hydroxy-Directed Hydroaluminations: A Stereoselective Approach to Cycloalkanols From β-Aryl Enones.
Koch, Kevin,Smitrovich, Jacqueline H.
, p. 1137 - 1140 (2007/10/02)
Various aryl substituted enones are reduced using lithium aluminum hydride to afford sterioselectively trans substituted alkanols.Mechanistic studies demonstrate 1,2-addition followed by hydroxy-directed hydroalumination of the conjugated styryl unit.
