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2216-17-3

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2216-17-3 Usage

General Description

N,N-Diethyl-O-nitroaniline is a chemical compound used in the production of dyes and pigments. It is a yellow crystalline solid with the molecular formula C10H14N2O2. N,N-DIETHYL-O-NITROANILINE is commonly used as an intermediate in the synthesis of azo dyes, which are widely used in various industries including textiles, plastics, and printing. N,N-Diethyl-O-nitroaniline is known for its high solubility in organic solvents and its ability to react with various reagents to form a wide range of colorants with different properties. However, it is important to handle this chemical with caution as it can be toxic if ingested or inhaled, and it may cause skin and eye irritation upon contact. Proper safety measures should be employed when working with N,N-Diethyl-O-nitroaniline to mitigate any potential health risks.

Check Digit Verification of cas no

The CAS Registry Mumber 2216-17-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,1 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2216-17:
(6*2)+(5*2)+(4*1)+(3*6)+(2*1)+(1*7)=53
53 % 10 = 3
So 2216-17-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2O2/c1-3-11(4-2)9-7-5-6-8-10(9)12(13)14/h5-8H,3-4H2,1-2H3

2216-17-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name N,N-Diethyl-2-nitroaniline

1.2 Other means of identification

Product number -
Other names Benzenamine, N,N-diethyl-2-nitro-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2216-17-3 SDS

2216-17-3Relevant articles and documents

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity

Bailey, Brodie L.,Nguyen, William,Ngo, Anna,Goodman, Christopher D.,Gancheva, Maria R.,Favuzza, Paola,Sanz, Laura M.,Gamo, Francisco-Javier,Lowes, Kym N.,McFadden, Geoffrey I.,Wilson, Danny W.,Laleu, Beno?t,Brand, Stephen,Jackson, Paul F.,Cowman, Alan F.,Sleebs, Brad E.

, (2021/08/30)

Malaria is a devastating parasitic disease caused by parasites from the genus Plasmodium. Therapeutic resistance has been reported against all clinically available antimalarials, threatening our ability to control the disease and therefore there is an ongoing need for the development of novel antimalarials. Towards this goal, we identified the 2-(N-phenyl carboxamide) triazolopyrimidine class from a high throughput screen of the Janssen Jumpstarter library against the asexual stages of the P. falciparum parasite. Here we describe the structure activity relationship of the identified class and the optimisation of asexual stage activity while maintaining selectivity against the human HepG2 cell line. The most potent analogues from this study were shown to exhibit equipotent activity against P. falciparum multidrug resistant strains and P. knowlesi asexual parasites. Asexual stage phenotyping studies determined the triazolopyrimidine class arrests parasites at the trophozoite stage, but it is likely these parasites are still metabolically active until the second asexual cycle, and thus have a moderate to slow onset of action. Non-NADPH dependent degradation of the central carboxamide and low aqueous solubility was observed in in vitro ADME profiling. A significant challenge remains to correct these liabilities for further advancement of the 2-(N-phenyl carboxamide) triazolopyrimidine scaffold as a potential moderate to slow acting partner in a curative or prophylactic antimalarial treatment.

Zinc Chloride Complexes with Aliphatic and Aromatic Guanidine Hybrid Ligands and Their Activity in the Ring-Opening Polymerisation of d,l-Lactide

Metz, Angela,Plothe, Ramona,Glowacki, Britta,Koszalkowski, Andreas,Scheckenbach, Michael,Beringer, Andreas,R?sener, Thomas,Michaelis de Vasconcellos, Janna,Haase, Roxana,Fl?rke, Ulrich,Hoffmann, Alexander,Herres-Pawlis, Sonja

, p. 4974 - 4987 (2016/11/09)

The synthesis of the new hybrid guanidine ligands DMEGdmap, DMEGdeae, TMGdmab, DMEGdmab, TMGdeab and DMEGdeab is reported. These ligands were combined with zinc chloride, and the six obtained new complexes were structurally characterised by X-ray crystall

Synthesis of benzimidazoles via iridium-catalyzed acceptorless dehydrogenative coupling

Sun, Xiang,Lv, Xiao-Hui,Ye, Lin-Miao,Hu, Yu,Chen, Yan-Yan,Zhang, Xue-Jing,Yan, Ming

supporting information, p. 7381 - 7383 (2015/07/15)

Iridium-catalyzed acceptorless dehydrogenative coupling of tertiary amines and arylamines has been developed. A number of benzimidazoles were prepared in good yields. An iridium-mediated C-H activation mechanism is suggested. This finding represents a novel strategy for the synthesis of benzimidazoles.

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