221649-19-0Relevant academic research and scientific papers
Enantioselective α-arylation of cyclohexanones with diaryl iodonium salts: Application to the synthesis of (-)-epibatidine
Aggarwal, Varinder K.,Olofsson, Berit
, p. 5516 - 5519 (2007/10/03)
(Chemical Equation Presented) Short cut: Direct asymmetric α-arylation of prochiral ketones has been effected using chiral lithium amide bases and diaryl iodonium salts. The methodology has been employed in a short total synthesis of the alkaloid (-)-epibatidine (see scheme).
