221684-53-3

Upstream product

• 221684-52-2 methyl 3-benzoyloxy-2-hydroxybenzoate 
• 74-88-4 methyl iodide 
• 303-38-8 2,3-Dihydroxybenzoic acid 
• 2411-83-8 methyl-2,3-dihydroxybenzoate 

Downstream Products

• 221684-57-7 methyl 2,2-dimethoxy-3-(triethylsilyl)oxy-3-<(Z)-hexa-1,5-diyne-3-ene>cyclohex-4,6-diene-1-carboxylate 
• 221684-55-5 methyl 2,2-dimethoxy-3-hydroxy-3-<(Z)-6-triisopropylsilylhexa-1,5-diyne-3-ene>cyclohex-4,6-diene-1-carboxylate 
• 221684-58-8 2,2-dimethoxy-3-(triethylsilyl)oxy-3-<(Z)-hexa-1,5-diyne-3-ene>cyclohex-4,6-diene-1-carbinol 
• 221684-59-9 2,2-dimethoxy-3-(triethylsilyl)oxy-3-<(Z)-hexa-1,5-diyne-3-ene>cyclohex-4,6-diene-1-carboxaldehyde 
• 221684-56-6 methyl 2,2-dimethoxy-3-hydroxy-3-<(Z)-hexa-1,5-diyne-3-ene>cyclohex-4,6-diene-1-carboxylate 
• 221684-54-4 methyl 2,2-dimethoxy-3-oxo-cyclohexa-4,6-diene-1-carboxylate 
• 2169-25-7 methyl 3′-hydroxy-2′-methoxybenzoate 

Relevant academic research and scientific papers

Dimerization of o-hydroxycyclohexadienones related to calicheamicinone: S(N)2 displacement of the 12α-hydroxyl group

Deprotection of the readily available bicyclo[7,3,1]enediyne alcohol 14 resulted in dimerization to give 18. Replacement of the 12α-hydroxyl group with a p-methoxyanilino group proceeded with overall retention to give 23 which also produced a dimer on attempted deprotection.