221684-54-4Relevant academic research and scientific papers
α-Halogenation as a Strategy to Functionalize Cyclohexa-2,4-dienones
Chittimalla, Santhosh Kumar,Koodalingam, Manikandan,Gadi, Vinod Kumar,Anaspure, Prasad
supporting information, p. 475 - 480 (2017/02/24)
A facile pyridine-mediated α-halogenation approach to functionalize cyclohexa-2,4-dienones is developed. A range of reactions, including organometallic coupling protocols, have been applied on these newly obtained halogenated cyclohexa-2,4-dienones, and the results are presented herein.
Unanticipated participation of HCl in nucleophilic chlorination reaction: Expedient route to meta chlorophenols
Chittimalla, Santhosh Kumar,Bandi, Chennakesavulu
supporting information, p. 15 - 19 (2015/12/23)
o-Quinone monoketals participated in a 1,4-addition reaction with HCl furnishing m-chlorophenols in high yields. Several readily available o-quinone monoketals were selected to display the generality of this serendipitous and unprecedented reaction and the results are presented herein.
Dimerization of o-hydroxycyclohexadienones related to calicheamicinone: S(N)2 displacement of the 12α-hydroxyl group
Churcher, Ian,Hallett, David,Magnus, Philip
, p. 1597 - 1606 (2007/10/03)
Deprotection of the readily available bicyclo[7,3,1]enediyne alcohol 14 resulted in dimerization to give 18. Replacement of the 12α-hydroxyl group with a p-methoxyanilino group proceeded with overall retention to give 23 which also produced a dimer on attempted deprotection.
