2217-56-3Relevant articles and documents
Clean production process for producing nitrobenzene alkoxy ether by using nitrohalogenated benzene
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Paragraph 0068-0073, (2020/06/09)
The invention provides a clean production process for producing nitrobenzene alkoxy ether by using nitrohalogenated benzene. The specific production steps comprise: proportionally adding one or more than one non-polar solvents into a reactor, adding molten nitrohalogenated benzene into the reactor, uniformly stirring, and adding alkali metal alkoxide into the reactor at a constant speed; after thereaction is finished, adding water to washing the inorganic matters generated in the reaction process while recovering the solvent. According to the invention, the production process is simple, the catalyst separation efficiency in the reaction process is high, other substances irrelevant to the reaction are not added in the reaction process, the purity is high, the yield is high, byproducts arelow, the wastewater amount is low, and the reaction period is short; and the reaction device is operated in a totally-enclosed manner, so that the operation environment is improved, the harm to humanhealth is reduced, and the cost is saved.
Metal- and Phenol-Free Synthesis of Biaryl Ethers: Access to Dibenzobistriazolo-1,4,7-oxadiazonines and Vancomycin-Like Glyco-Macrocycles as Antibacterial Agents
Singh, Kartikey,Sharma, Gaurav,Shukla, Manjulika,Kant, Ruchir,Chopra, Sidharth,Shukla, Sanjeev K.,Tripathi, Rama P.
, p. 14882 - 14893 (2018/12/14)
An efficient synthesis of biaryl ethers, from electron-deficient aryl halides using NaH/DMSO under metal- and phenol-free conditions, has been achieved to access dibenzo-bistriazolo-1,4,7-oxadiazonines and vancomycin-like glyco-macrocycles. A 44-membered glyco-macrocycle showed promising activity against vancomycin-resistant Staphylococcus aureus (VRSA).
Palladium-catalysed and phosphine-promoted synthesis of diaryl ethers through self-coupling
Wang, Dawei,Xu, Zhaojun,Yu, Xiaoli,Li, Yongliang,Wan, Huida
, p. 691 - 693 (2016/11/18)
An efficient, palladium acetate-catalysed, tributylphosphine-promoted direct synthesis of symmetrical diaryl ethers through the self-coupling of aryl fluorides has been developed with K2CO3/ZrO2 as a base. This provides an alternative method to prepare aromatic polymers, important synthetic intermediates and natural products for use in the field of pharmaceuticals and industrial materials.