221874-51-7

Usage

Uses

Used in Pharmaceutical Industry:
Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Pesticide Industry:
In the pesticide industry, tert-butyl carbamate is utilized as a key component in the formulation of certain insecticides and herbicides. Its chemical properties enable it to effectively control pests and weeds, contributing to increased crop yields and protection of agricultural resources.
Used as a Reagent in Organic Synthesis:
Carbamic acid, [(3R)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI) serves as a valuable reagent in organic synthesis, facilitating various chemical reactions and transformations. Its ability to participate in a range of reactions, such as esterification, amidation, and acylation, makes it a useful tool for chemists in the synthesis of complex organic molecules.
Used as a Solvent in Chemical Processes:
Tert-butyl carbamate is employed as a solvent in various chemical processes due to its ability to dissolve a wide range of substances. Its solubility properties, combined with its stability under certain reaction conditions, make it a suitable choice for use in processes that require a non-reactive, polar solvent.

InChI:InChI=1/C10H18N2O3/c1-10(2,3)15-9(14)12-7-5-4-6-11-8(7)13/h7H,4-6H2,1-3H3,(H,11,13)(H,12,14)/t7-/m1/s1

Upstream product

• 159877-12-0 (R)-5-amino-2-((tert-butoxycarbonyl)amino)pentanoic acid 
• 16682-12-5 D-ornithine hydrochloride 
• 2480-93-5 (R)-Nδ-benzyloxycarbonyl-Nα-(tert-butoxycarbonyl)-ornithine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 88763-76-2 (R)-(+)-3-Amino-2-piperidinon 

Downstream Products

• 1256385-95-1 ((R)-3-tert-Butoxycarbonylamino-2-oxo-piperidin-1-yl)-acetic acid benzyl ester 
• 82611-51-6 3(R)--2-oxo-1-piperidineacetic acid 
• 309956-78-3 (R)-piperidin-3-ylcarbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Convenient synthesis of (R)-3-[(tert -Butoxycarbonyl)amino]piperidine and (R)-3-[(tert -Butoxycarbonyl)amino]azepane

(R)-3-[(tert -Butoxycarbonyl)amino]piperidine and (R)-3-[(tert -butoxycarbonyl)amino]azepane were prepared in two steps starting from d -ornithine and d -lysine, respectively. In the key step, N -Boc-protected 3-aminolactams were converted into imido esters by O-alkylation and then hydrogenated to amines, under mild conditions (5 bar H 2, room temperature) and without isolation, over a standard hydrogenation catalyst (5% Pt/C).

Its use as an inhibitor and JAK and SYK deriv. pyrroropyrazine

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q, R2, R3, and Y are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Heterocyclic substituted aminoazacycles useful as central nervous system agents

Heterocyclic substituted aminoazacyclic compounds of the formula (I):Z-R3, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.

Total syntheses of cepaciamides A and B, novel fungitoxic 3-amino-2- piperidinone-containing lipids produced by Pseudomonas cepacia D-202

Total syntheses of cepaciamides A and B were accomplished. (R)-3-Amino- 2-piperidinone was obtained via cyclization of (R)-ornithine. The common amide-linked fatty acid was synthesized via Sharpless AD as the key step. Amide-formation was achieved with DEPC. In the preparation of two fatty acid segments, (S)-malic acid was used as the chiral source to introduce (2S)- configuration. A known chiral cyclopropane derivative was introduced in the segment of cepaciamide A. The formation of (Z)-olefin in the segment of cepaciamide B was achieved by means of partial reduction of the acetylenic bond. Esterification between the fatty acid-segments and the amide-segment with DCC/DMAP and subsequent oxidative deprotection of the MPM group with CAN gave cepaciamides.

Study on fungitoxic 3-amino-2-piperidinone-containing lipids: Revised structure of cepaciamide A and structural determination of its closely related lipid, cepaciamide B

The structure of cepaciamide A was revised to be (3R,3'S,2'S,11'S,12'R)- 3-[3'-(2'hydroxy-11', 12'-methylencoetadecanoyloxy)hexadecamido]-2- piperidinone with respect to the absolute configuration of the C3- and C2- positions and the position of the cyclopropane ring by using synthetic methods. The structure of cepaciamide B was also determined to be (3R,3'S,2'S, 11'Z)'3'[3'(2'-hydroxy-11-octadecenoyloxy)hexadecamido]-2- piperidinone.