2219-66-1

Basic information

• Product Name: 1,4-DIBROMO-2-BUTYNE
• Synonyms: 1,4-DIBROMO-2-BUTYNE;1,4-dibromo-2-butyn;1,4-dibromobut-2-yne;4-Dibromo-2-butyne
• CAS NO: 2219-66-1
• Molecular Formula: C₄H₄Br₂
• Molecular Weight: 211.88
• EINECS: 218-731-0
• Mol File: 2219-66-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 164.23°C (rough estimate)
• Flash Point: 91.5 °C
• Appearance: /
• Density: 2.0140
• Vapor Pressure: 0.166mmHg at 25°C
• Refractive Index: 1.5880
• CAS DataBase Reference: 1,4-DIBROMO-2-BUTYNE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DIBROMO-2-BUTYNE(2219-66-1)
• EPA Substance Registry System: 1,4-DIBROMO-2-BUTYNE(2219-66-1)

Safety Data

• Hazardous Substances Data: 2219-66-1(Hazardous Substances Data)

Usage

General Description

1,4-DIBROMO-2-BUTYNE is a synthetic, organic chemical compound categorized as an alkene and an alkyne. This colorless-to-yellow liquid is notable for its four carbon atoms which are linked in a chain, with a bromine atom attached to each end and a triple bond between the two interior carbon atoms. Moreover, its strong, pungent smell is discernible. In the industrial field, it is chiefly employed as an intermediate reagent in organic synthesis processes for manufacturing diverse chemical products such as pharmaceuticals or polymers. It's vital to handle it with care due to its notable flammability and potential health hazards; it may cause serious eye damage and skin irritation upon contact, and potentially harmful if inhaled or swallowed.

InChI:InChI=1/C4H4Br2/c5-3-1-2-4-6/h3-4H2

Upstream product

• 110-65-6 1,4-dihydroxybut-2-yne 
• 7789-60-8 phosphorus tribromide 
• 71-43-2 benzene 
• 2873-50-9 butatriene 
• 67-66-3 chloroform 
• 6337-59-3 2-butyne-1,4-ditosylate 

Downstream Products

• 108839-34-5 3,3'-dimethyl-4,4'-but-2-ynediyldioxy-di-benzonitrile 
• 113651-87-9 N,N'-bis-(2,6-dimethyl-phenyl)-N,N'-dimethyl-but-2-ynediyldiamine 
• 90772-50-2 1-bromo-4-phenyloxy-2-butyne 
• 1942-45-6 4-Octyne 
• 29569-67-3 2-((E)-2,3-Dibromo-but-2-enyl)-3-hydroxy-5,5-dimethyl-cyclohex-2-enone 
• 29508-75-6 C₂₀H₂₆O₄ 
• 18495-27-7 1-bromooct-2-yne 
• 2219-70-7 3-(bromomethyl)hepta-1,2-diene 
• 16400-32-1 1-bromo-pent-2-yne 
• 18495-25-5 1-bromohex-2-yne 
• 2219-67-2 3-bromomethyl-penta-1,2-diene 
• 503323-43-1 (5-bromopent-3-yn-1-yl)benzene 
• 2219-55-8 3-bromomethyl-4-phenyl-1,2-butadiene 
• 1072-20-4 Octatriin-(2,4,6) 

Relevant articles and documents

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1,2-Dibromotetrachloroethane: An efficient reagent for many transformations by modified Appel reaction

An efficient and facile method has been developed for the synthesis of alkyl bromides from various alcohols under mild conditions using a triphenylphosphine (PPh 3) /1,2-dibromotetrachloroethane (DBTCE) complex in excellent yields and very short time (5 min). This method can also be applied for the transformation of chiral alcohols to their corresponding bromides in very high enantiomeric excess. The PPh 3 /DBTCE complex is also successfully applied to ring-opening reactions of cyclic ethers in mild conditions. Esterification, amidation, and formation of acid anhydrides under very mild experimental conditions are also successfully accomplished by following a modification of the Appel reaction protocol in this work.

A new synthetic route for the synthesis of enantioenriched 1,2,3,4-tetrahydronaphthalene-derived 1,3-diols

In this report, we presented a new approach to access a (1,3-butadiene-2-yl)carbinol, (1R,2R)- and (1S,2S)-1-(hydroxymethyl)-1-vinyl-1,2,3,4-tetrahydronaphthalene-2-ols. Starting from commercially available 1,4-diol-2-butyne, a six-step synthesis involving dibromination, Zn-mediated addition reaction of phenylpropyl aldehyde, epoxidation, epoxy–arene cyclization, and resolution with D(+)-Camphor afforded the title compounds.