50741-36-1

Basic information

• Product Name: 1,2,3,4-Tetrahydroquinoline-6-carbonitrile
• Synonyms: 1,2,3,4-Tetrahydroquinoline-6-carbonitrile;6-Cyano-1,2,3,4-tetrahydroquinoline;1,2,3,4-Tetrahydro-6-quinolinecarbonitrile
• CAS NO: 50741-36-1
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.1998
• Mol File: 50741-36-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 77-79 °C
• Boiling Point: 322.9±31.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.76±0.20(Predicted)
• CAS DataBase Reference: 1,2,3,4-Tetrahydroquinoline-6-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydroquinoline-6-carbonitrile(50741-36-1)
• EPA Substance Registry System: 1,2,3,4-Tetrahydroquinoline-6-carbonitrile(50741-36-1)

Safety Data

• Hazardous Substances Data: 50741-36-1(Hazardous Substances Data)

Usage

General Description

1,2,3,4-Tetrahydroquinoline-6-carbonitrile is a chemical compound that belongs to the class of quinoline derivatives. It is commonly used as a building block in organic synthesis, and its structure consists of a quinoline ring with a carbonitrile group at position 6. 1,2,3,4-Tetrahydroquinoline-6-carbonitrile has various potential applications in medicinal chemistry, as it has been investigated for its potential as a drug candidate, particularly for its antitumor and anti-inflammatory properties. Additionally, 1,2,3,4-Tetrahydroquinoline-6-carbonitrile has also been studied for its potential use as a corrosion inhibitor in metal protection, as well as its role in the development of new materials for industrial and pharmaceutical purposes. Overall, 1,2,3,4-Tetrahydroquinoline-6-carbonitrile is a versatile compound with wide-ranging applications in both chemical and biological fields.

Upstream product

• 22190-35-8 6-bromo-1,2,3,4-tetrahydroquinoline 
• 557-21-1 dicyanozinc 
• 23395-72-4 quinoline-6-carbonitrile 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 787631-77-0 C₁₇H₁₅BrN₂ 
• 23395-72-4 quinoline-6-carbonitrile 
• 1384850-27-4 3-(6-carbamoyl-1,2,3,4-tetrahydroquinolin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylic acid 
• 1384850-56-9 methyl 3-(6-cyano-1,2,3,4-tetrahydroquinolin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate 
• 1384850-25-2 3-(6-cyano-1,2,3,4-tetrahydroquinolin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylic acid 
• 853021-78-0 4-{1-{N-[4-(4-methoxyphenyl)but-1-yl]aminoethyl}-2-(3,5-dimethylphenyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-8-oyl}morpholine 
• 853021-75-7 N-[4-(4-methoxyphenyl)but-1-yl]-2-[8-ethoxycarbonyl-2-(3,5-dimethylphenyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl]-2-oxoacetamide 
• 853021-76-8 ethyl 1-{N-[4-(4-methoxyphenyl)but-1-yl]aminoethyl}-2-(3,5-dimethylphenyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-8-carboxylate 
• 853021-77-9 1-{N-[4-(4-methoxyphenyl)but-1-yl]aminoethyl}-2-(3,5-dimethylphenyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-8-carboxylic acid 
• 853021-72-4 ethyl 8-(3,5-dimethylphenyl)ethynyl-1,2,3,4-tetrahydroquinoline-6-carboxylate 
• 853021-65-5 ethyl 2-(3,5-dimethylphenyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-8-carboxylate 
• 853021-71-3 6-cyano-8-(3,5-dimethylphenyl)ethynyl-1,2,3,4-tetrahydroquinoline 
• 5382-49-0 1,2,3,4-tetrahydroquinoline-6-carboxylic acid 

Relevant articles and documents

Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model

Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6 inhibitor (HDAC6i) bearing a tetrahydroquinoline (THQ) capping group, is a highly potent and sel

Simple manganese carbonyl catalyzed hydrogenation of quinolines and imines

Manganese-catalyzed hydrogenation of unsaturated molecules has made tremendous progresses recently benefiting from non-innocent pincer or bidentate ligands for manganese. Herein, we describe the hydrogenation of quinolines and imines catalyzed by simple manganese carbonyls, Mn2(CO)10 or MnBr(CO)5, thus eliminating the prerequisite pincer-type or bidentate ligands.

Method for conducting catalytic hydrogenation on nitrogen-containing unsaturated heterocyclic compound

The invention provides a method for conducting catalytic hydrogenation on a nitrogen-containing unsaturated heterocyclic compound, and belongs to the technical field of catalytic hydrogenation. The provided method for conducting catalytic hydrogenation on the nitrogen-containing unsaturated heterocyclic compound comprises the following step: in the presence of hydrogen and a manganese catalyst, with the nitrogen-containing unsaturated heterocyclic compound as a substrate, carrying out a hydrogenation reaction. According to the method for conducting catalytic hydrogenation on the nitrogen-containing unsaturated heterocyclic compound, he adopted manganese catalyst is an NNP-type pincer manganese catalyst, has the advantages of being cheap, easy to obtain and low in toxicity compared with noble metal catalysts, has the advantages of being wide in substrate applicability and high in target product yield compared with an existing cheap metal iron catalyst or cobalt catalyst, and is higher in electron donating ability and smaller in steric hindrance compared with a PNP-type pincer manganese catalyst, and thus shows higher reaction activity in a series of hydrogenation reactions, and thetarget product yield is up to 99%.