22190-40-5

Basic information

• Product Name: 1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline
• Synonyms: 1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline;Einecs 244-829-8;1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline(SALTDATA: FREE)
• CAS NO: 22190-40-5
• Molecular Formula: C₁₁H₁₂BrNO
• Molecular Weight: 254.12308
• EINECS: 244-829-8
• Mol File: 22190-40-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 436.5°C at 760 mmHg
• Flash Point: 217.8°C
• Appearance: /
• Density: 1.454g/cm³
• Vapor Pressure: 8.07E-08mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.31±0.20(Predicted)
• CAS DataBase Reference: 1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline(22190-40-5)
• EPA Substance Registry System: 1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline(22190-40-5)

Safety Data

• Hazardous Substances Data: 22190-40-5(Hazardous Substances Data)

Usage

General Description

1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline is an organic compound with the chemical formula C12H13BrNO. It is a heterocyclic compound that contains a quinoline core and a bromine substituent at the 6-position. The acetyl group at the 1-position indicates the presence of a carbonyl group, giving the compound its characteristic odor and flavor. 1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline has potential applications in pharmaceutical and medicinal chemistry due to its quinoline scaffold, which is found in a variety of bioactive molecules. Its synthesis and properties are of interest to researchers in the field of organic chemistry, and it may have potential for further development as a drug candidate or as a chemical building block in organic synthesis.

InChI:InChI=1/C11H12BrNO/c1-8(14)13-6-2-3-9-7-10(12)4-5-11(9)13/h4-5,7H,2-3,6H2,1H3

Upstream product

• 4169-19-1 1-acetyl-1,2,3,4-tetrahydroquinoline 
• 22190-35-8 6-bromo-1,2,3,4-tetrahydroquinoline 
• 75-36-5 acetyl chloride 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 5263-87-6 6-methoxy quinoline 

Downstream Products

• 851202-94-3 1-acetyl-1,2,3,4-tetrahydroquinoline-6-carbonitrile 

Relevant articles and documents

CANCER TREATMENTS TARGETING CANCER STEM CELLS

Disclosed are compounds, methods, compositions, and kits that allow for treating cancer by, e.g., targeting cancer stem cells. In some embodiments, the cancer is colorectal cancer, gastric cancer, gastrointestinal stromal tumor, ovarian cancer, lung cancer, breast cancer, pancreatic cancer, prostate cancer, testicular cancer, or lymphoma. In some embodiments, the cancer is liver cancer, endometrial cancer, leukemia, or multiple myeloma. The compounds utilized in the disclosure are of Formula (0), (O'), and (I):

THERAPEUTIC COMPOUNDS AND USES THEREOF

The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R5-R6 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

N-THIAZOL-2-YL-BENZAMIDE DERIVATIVES

The invention relates to N-thiazol-2-yl-benzamide derivatives of the formula I in the description wherein the variables are as defined in the claims. The compounds are A2A-receptor ligands, such as antagonists, agonists, reverse agonists or partial agonists, and are useful in the treatment of neurological and psychiatric disorders where an A2A-receptor is implicated.