22192-02-5

Basic information

• Product Name: ethyl 2,6-dimethyl-4-oxo-1,4-dihydropyridine-3-carboxylate
• Synonyms: 3-pyridinecarboxylic acid, 4-hydroxy-2,6-dimethyl-, ethyl ester; Ethyl 4-hydroxy-2,6-dimethylnicotinate
• CAS NO: 22192-02-5
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.2151
• Mol File: 22192-02-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 304.6°C at 760 mmHg
• Flash Point: 138°C
• Density: 1.124g/cm³
• Vapor Pressure: 0.000863mmHg at 25°C
• Refractive Index: 1.496
• CAS DataBase Reference: ethyl 2,6-dimethyl-4-oxo-1,4-dihydropyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,6-dimethyl-4-oxo-1,4-dihydropyridine-3-carboxylate(22192-02-5)
• EPA Substance Registry System: ethyl 2,6-dimethyl-4-oxo-1,4-dihydropyridine-3-carboxylate(22192-02-5)

Safety Data

• Hazardous Substances Data: 22192-02-5(Hazardous Substances Data)

Upstream product

• 21731-17-9 methyl 3-aminocrotonate 
• 31588-29-1 methyl 1,4-dihydro-2,6-dimethyl-4-oxopyridine-3-carboxylate 
• 3222-61-5 3-amino-pent-2-enoic acid ethyl ester 
• 105-45-3 acetoacetic acid methyl ester 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 626-34-6 ethyl aminocrotonate 

Downstream Products

• 948350-96-7 2,6-dimethyl-4-(toluene-4-sulfonylamino)-nicotinic acid ethyl ester 

Relevant articles and documents

NOVEL DUAL ACTION RECEPTORS ANTAGONISTS (DARA) AT THE AT1 AND ETA RECEPTORS

The present invention relates to new compounds of the formula [Chemical formula should be inserted here. Please see paper copy] wherein R1, R2, R3, and R31 are as specified herein. The invention also relates to a method for preparation thereof, as well as combinations of the new compounds with previously known agents. The invention also relates to the use of the above-mentioned compounds and combinations for the preparation of a medicament for treating hypertension of different kinds, alleviating organ damage of different kinds, treating or preventing diabetic nephropathy, treating endothelin and angiotensin mediated disorders, and treating prostate cancer.

Reaction of Diketene-Acetone Adduct with Enamines, Ketene Acetals, Vinyl Ethers, and β-Diketones

Diketene-acetone adduct (1) generates acetylketene (2) under heating.In order to compare the reactivity of 2 with that of diketene, the reaction of 1 with electron-rich olefins was investigated.On heating with 1 primary enamines (3a-d) produced the corresponding 3-substituted 2,6-dimethyl-4(1H)-pyridones (4a-d), while the tertiary enamine 3e gave the 4-pyrone derivative (7).The reaction of 1 with ketene acetals (8) gave the 2,2-diethoxy-2,3-dihydro-4-pyrone derivatives (9).The vinyl ether derivatives 13 similarly reacted with 1 to give the 4-pyrone derivative 15 or 16 as the major product.The result shows that both diketene and 2 react with electron-rich olefins in a similar manner.Keywords -- diketene; acetylketene; diketene-acetone adduct; enamine; ketene acetal; vinyl ether; 1,3-dioxin-4-one; 4-pyridone; 4-pyrone; cycloaddition