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2220-04-4

1-(4-bromophenyl)-2-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)ethan-1-one is a complex organic compound with a molecular formula of C21H20BrNO4. It features a 4-bromophenyl group attached to the first carbon atom of the ethanone backbone, while the second carbon atom is connected to a 4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl moiety. 1-(4-bromophenyl)-2-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)ethan-1-one is characterized by its unique structure, which includes a tetrahydro[1,3]dioxolo[4,5-g]isoquinoline ring system, a 4-methoxy group, and a 6-methyl group. The presence of a bromine atom in the 4-position of the phenyl ring and the carbonyl group at the end of the ethanone backbone contribute to its chemical properties and potential applications in various fields, such as pharmaceuticals or materials science.

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  • 2220-04-4 Structure

  • Basic information

    1. Product Name: 1-(4-bromophenyl)-2-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)ethan-1-one
    2. Synonyms: 1-(4-bromophenyl)-2-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)ethan-1-one
    3. CAS NO:2220-04-4
    4. Molecular Formula:
    5. Molecular Weight: 418.287
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 2220-04-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(4-bromophenyl)-2-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)ethan-1-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(4-bromophenyl)-2-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)ethan-1-one(2220-04-4)
    11. EPA Substance Registry System: 1-(4-bromophenyl)-2-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)ethan-1-one(2220-04-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2220-04-4(Hazardous Substances Data)

2220-04-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2220-04-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,2 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2220-04:
(6*2)+(5*2)+(4*2)+(3*0)+(2*0)+(1*4)=34
34 % 10 = 4
So 2220-04-4 is a valid CAS Registry Number.

2220-04-4Downstream Products

2220-04-4Relevant articles and documents

Metal-Free Activation of C(sp3)–H Bond, and a Practical and Rapid Synthesis of Privileged 1-Substituted 1,2,3,4-Tetrahydroisoquinolines

Choudhury, Santosh Kumar,Rout, Pragati,Parida, Bibhuti Bhusan,Florent, Jean-Claude,Johannes, Ludger,Phaomei, Ganngam,Bertounesque, Emmanuel,Rout, Laxmidhar

, p. 5275 - 5292 (2017)

The reaction of cotarnine and acyl/aryl ketones in “green” solvents provides an efficient approach to an array of privileged 1,2,3,4-tetrahydroisoquinolines in excellent yields by metal-free activation of C(sp3)–H bonds. This one-pot procedure takes place under base-free conditions at room temperature, and tolerates a wide range of functionalities. The reaction is highly chemoselective, can be performed on a multi-gram scale, and pure products are isolated by simple filtration without workup. Interestingly, the complementary two-step procedure from cotarnine halide salts gives the Mannich products in good yields. The scope was elaborated to 9-bromocotarnine salts to access a range of 9-bromonoscapine-derived analogues. The methodology has been developed considering the structural similarity of cotarnine derivatives to noscapinoids, which represent an emerging class of microtubule-modulating anticancer agents.

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