Cas 22209-78-5,Cbz-D-Ala-L-Pro-OH

22209-78-5

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Basic information

Product Name: Cbz-D-Ala-L-Pro-OH
Synonyms: Cbz-D-Ala-L-Pro-OH
CAS NO:22209-78-5
Molecular Formula:
Molecular Weight: 320.345
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: Cbz-D-Ala-L-Pro-OH(CAS DataBase Reference)
NIST Chemistry Reference: Cbz-D-Ala-L-Pro-OH(22209-78-5)
EPA Substance Registry System: Cbz-D-Ala-L-Pro-OH(22209-78-5)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 22209-78-5(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 22209-78-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,0 and 9 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 22209-78:
(7*2)+(6*2)+(5*2)+(4*0)+(3*9)+(2*7)+(1*8)=85
85 % 10 = 5
So 22209-78-5 is a valid CAS Registry Number.

22209-78-5Upstream product

22209-78-5Downstream Products

22209-78-5Relevant academic research and scientific papers

A benzotriazole-mediated route to protected marine-derived hetero-2,5-diketopiperazines containing proline

Nsengiyumva, Olivier,Hamedzadeh, Sadra,McDaniel, James,Macho, Jocelyn,Simpson, Grant,Panda, Siva S.,Ha, Khanh,Lebedyeva, Iryna,Faidallah, Hassan M.,Al-Mohammadi, Manal Metgen,Hall, C. Dennis,Katritzky, Alan R.

, p. 4399 - 4403 (2015/04/14)

A procedure for the cyclization of dipeptidoyl benzotriazolides containing proline derivatives promoted by triethylamine under MW activation is introduced. The reaction is general for a variety of dipeptidoyl benzotriazolides and represents a very practical and convenient method for the preparation of Pro- or Hyp-derived 2,5-diketopiperazines (2,5-DKPs) and bis-DKPs with a disulfide linker. This method can be used for the construction of 2,5-DKP compound libraries and for the synthesis of natural products with diketopiperazine cores. This journal is

A new benzotriazole-mediated stereoflexible gateway to hetero-2,5- diketopiperazines

Monbaliu, Jean-Christophe M.,Hansen, Finn K.,Beagle, Lucas K.,Panzner, Matthew J.,Steel, Peter J.,Todadze, Ekaterina,Stevens, Christian V.,Katritzky, Alan R.

, p. 2632 - 2638 (2012/04/17)

Open chain Cbz-L-aa1-L-Pro-Bt (Bt=benzotriazole) sequences were converted into either the corresponding trans- or cis-fused 2,5- diketopiperazines (DKPs) depending on the reaction conditions. Thermodynamic tandem cyclization/epimerization afforded selectively the corresponding trans-DKPs (69-75%). Complementarily, tandem deprotection/cyclization led to the cis-DKPs (65-72%). A representative set of proline-containing cis- and trans-DKPs has been prepared. A mechanistic investigation, based on chiral HPLC, kinetics, and computational studies enabled a rationalization of the results. Stereoflexible route to DKPs: A convenient, versatile, and flexible benzotriazole-mediated methodology for the synthesis of proline-containing hetero-2,5-diketopiperazines (DKPs) is reported. Depending on the reaction conditions, either cis- or trans-configured DKPs were obtained starting from the same inexpensive l,l-dipeptidoyl benzotriazole key intermediate (see scheme). Kinetics, chiral HPLC, and computational studies forged a background for mechanistic rationalization. Copyright

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