2221-06-9

Usage

Uses

Used in Pharmaceutical Research:
Pirazolam is used as a research chemical for its potential anxiolytic and sedative properties. It is employed in scientific studies to explore its interactions with GABA receptors in the brain, which may contribute to its therapeutic effects.
Used in Neurological Applications:
In the field of neurology, Pirazolam is used as a psychoactive substance to study its potential in treating anxiety disorders and sleep disorders. Its interaction with GABA receptors may help in understanding its role in modulating neuronal activity and potentially alleviating symptoms associated with these conditions.
Used in Drug Development:
Pirazolam is utilized in drug development for the creation of new therapeutic agents targeting GABA receptors. Its psychoactive properties and potential anxiolytic and sedative effects make it a candidate for further research and development in the pharmaceutical industry.

Upstream product

• 92033-74-4 N-phenylcarbamoyl-L-leucine ; active α-(ω-phenyl-ureido)-isobutylacetic acid 
• 6322-53-8 leucine methyl ester hydrochloride 
• 103-71-9 phenyl isocyanate 
• 328-39-2 LEUCINE 
• 591-50-4 iodobenzene 
• 66003-76-7 Diphenyliodonium triflate 
• 67337-73-9 5-isobutyl-imidazolidine-2,4-dione 
• 88576-97-0 N-(N-phenylcarbamoyl-leucyl)-glycine 

Downstream Products

• 88576-98-1 (S)-5-isobutyl-3-phenylimidazolidine-2,4-dione 

Relevant academic research and scientific papers

Photochemical Deracemization at sp3-Hybridized Carbon Centers via a Reversible Hydrogen Atom Transfer

A photochemical deracemization of 5-substituted 3-phenylimidazolidine-2,4-diones (hydantoins) is reported (27 examples, 69%-quant., 80–99% ee). The reaction is catalyzed by a chiral diarylketone which displays a two-point hydrogen bonding site. Mechanistic evidence (DFT calculations, radical clock experiments, H/D labeling) suggests the reaction to occur by selective hydrogen atom transfer (HAT). Upon hydrogen binding, one substrate enantiomer displays the hydrogen atom at the stereogenic center to the photoexcited catalyst allowing for a HAT from the substrate and eventually for its conversion into the product enantiomer. The product enantiomer is not processed by the catalyst and is thus enriched in the photostationary state.

N1- and N3-Arylations of Hydantoins Employing Diaryliodonium Salts via Copper(I) Catalysis at Room Temperature

Copper(I)-catalyzed N-arylation (both N1- and N3-) of hydantoins with diaryliodonium salts as aryl partners at room temperature is reported. The transformation allows diverse scopes on both hydantoins and diaryliodonium salts deliver

Microwave-assisted solid-phase synthesis of hydantoin derivatives

A microwave-assisted synthesis of 3,5- and 1,3,5-substituted hydantoins starting from various resins for solid-phase combinatorial chemistry has been developed. The hydantoins were synthesized from pre-loaded resins with amino acids via treatment with isocyanate or phenylisocyanate and subsequent intramolecular cyclization. Both reactions were performed under microwave irradiation. We studied the cyclative cleavage leading to hydantoin compounds dependent on the nature of the amino acid and the nucleofuge properties of the resin.