2221-68-3

Upstream product

• 121666-50-0 4-acetylhex-3-enone 1-ethylene ketal 
• 121666-58-8 methyl 7-ethylenedioxydecahydro-4-oxo-1-(trimethylsilyl)naphthalene-1-carboxylate 
• 127075-61-0 3,4,4aβ,5,6,7,8,8aα-octahydro-5-methylene-8α-vinylnaphthalen-2(1H)-one ethylene ketal 
• 127075-59-6 (4aβ,8aα)-decahydro-8α-hydroxymethyl-5-methylenenaphthalen-2(3H)-one ethylene ketal 
• 127075-55-2 (4aβ,8aα)-7-ethylenedioxydecahydro-4-methylenenaphthalene-1α-carbaldehyde 
• 127075-54-1 methyl (4aβ,8aα)-7-ethylenedioxydecahydro-4-methylenenaphthalene-1α-carboxylate 
• 127075-53-0 methyl (4aβ,8aα)-7-ethylenedioxydecahydro-4-oxonaphthalene-1α-carboxylate 
• 121666-51-1 4-<1-(trimethylsiloxy)vinyl>cyclohex-3-enone 1-ethylene ketal 
• 127075-56-3 3,4,4aβ,5,6,7,8,8aα-octahydro-5-methylene-8α-vinylnaphthalen-2(1H)-one 
• 75-09-2 dichloromethane 

Relevant academic research and scientific papers

Annulation by Sequential Doubla Michael Reaction; Synthesis of Decalones and Its Application to the Syntheses of ε-Cadinene, Khusitone and Khusilal

Reaction of kinetic enolates or the trimethylsilyl enol ethers of 1-acetylcyclohexenes with α,β-unsaturated carbonyl compounds affords 4-substituted 1-decalone derivatives under basic or Lewis acidic conditions.The reaction with acrylates of chiral alcohols has achieved 70percent diastereoselection.Application of these reactions has enabled syntheses of ε-cadinene, khusitone and khusial to be accomplished.

A Synthesis of (+/-)-Khusilal

(+/-)-Khusilal, a C14-terpenoid isolated from North Indian vetiver oil, has been synthesized from the decalone derivative prepared by a double Michael reaction.