22236-91-5Relevant academic research and scientific papers
Surprising formylations with methylformamidopyridines and oxalyl chloride
Cheng, Ying,Liu, Qing-Xiang,Meth-Cohn, Otto
, p. 3475 - 3478 (2000)
4-N-(Methylformamido)pyridine with (COCl)2 gives the corresponding Vilsmeier reagent which reacts with 4-substituted dimethylanilines to produce 5-substituted-N-methylisatins. The corresponding 2-N- (methylformamido)pyridine under the same conditions generates benzo[2,3]pyrido[6,7-b][1,5]diazocines. (C) 2000 Elsevier Science Ltd.
KOtBu-Promoted Transition-Metal-Free Transamidation of Primary and Tertiary Amides with Amines
Ghosh, Tridev,Jana, Snehasish,Dash, Jyotirmayee
supporting information, p. 6690 - 6694 (2019/09/12)
This work discloses transamidation of primary and tertiary amides with a range of aryl, heteroaryl, and aliphatic amines using potassium tert-butoxide. The reaction proceeds at room temperature under transition-metal-free conditions providing secondary amides in high yields. Moreover, reaction of cyclopropyl amine with tertiary amides proceeds with ring-opening to provide a rapid access to enamides.
Deep eutectic solvent promoted highly efficient synthesis of N, N'-diarylamidines and formamides
Azizi, Najmadin,Gholibeglo, Elham,Babapour, Mahbobe,Ghafuri, Hossein,Bolourtchian, Seyed Mohammad
, p. 768 - 773 (2012/10/30)
A deep eutectic solvent was used as a dual catalyst and reaction medium for the efficient N-formylation of aromatic amines without hazardous organic solvent and catalyst. Treatment of aromatic amines with trimethyl orthoformate and formic acid in deep eutectic solvent at 70 °C gives the corresponding N-formyl derivatives in good to excellent yields. This simple ammonium deep eutectic solvent, easily synthesized from choline chloride and SnCl2, with 100% atom economy and making it applicable to industry and laboratory. Furthermore, heating the trimethyl orthoformate and aromatic primary amines in the deep eutectic solvent results in formation of the corresponding N,N'-diarylamidines in high yields.
PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
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Page/Page column 24-25, (2008/12/04)
This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
A NEW METHOD FOR THE PREPARATION OF SUBSTITUTED 2-PYRIMIDINYL- AND s-TRIAZINYL-FORMAMIDE OXIMES. FORMYLATION OF HETEROCYCLIC AMINES WITH TRISFORMAMINOMETHANE
Stanovnik, Branko,Zmitek, Janko,Tisler, Miha
, p. 2173 - 2176 (2007/10/02)
A novel method for the preparation of substituted 2-pyrimidinyl- and s-triazinyl-formamide oximes is described.Heterocyclic amines 1 are first converted with trisformaminomethane, as the most powerful formylating agent, into formylamino derivatives 3.These give by treatment with hydroxylamine the corresponding formamide oximes 4 in yields up to 95percent.
