22238-90-0Relevant academic research and scientific papers
Synthesis of 3-Glycofuranosyl-5-aminopyrazolopyrimidine-7-thiones: Thioguanosine-Type C-Nucleosides
Acton, Edward M.,Ryan, Kenneth J.
, p. 528 - 536 (2007/10/02)
The first C-nucleosides of the thioguanosine type are the 3-β-D-ribofuranosyl, 3-β-D-arabinofuranosyl, and 3-(2-deoxy-β-D-erythro-pentofuranosyl)derivatives of 5-aminopyrazolopyrimidine-7-thione.Synthesis of these products employed C6H5CH2SC(Cl)=NCOC6H5 as a new reagent for ring closure of the 3-glycofuranosyl-4-aminopyrazole-5-carbothiamide precursors.The new ring closure requires fewer steps and minimizes side reactions encountered in previous guanosine ring closure.The amino thioamide precursors are prepared from pyrazole C-nucleosides available as in previous formycin syntheses.
