222422-33-5

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 67947-08-4 (RS)-4-oxiranylmethyl-phenol 
• 1122-58-3 dmap 
• 501-92-8 4-(prop-2-enyl)phenol 
• 140-67-0 Estragole 

Downstream Products

• 375856-64-7 1-(4-benzyl-piperidin-1-yl)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propan-2-ol 
• 222422-32-4 (RS)-4-Benzyl-1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-propyl}-piperidin-4-ol 
• 375856-66-9 1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-propyl}-4-(4-chloro-benzyl)-piperidin-4-ol 
• 375856-65-8 1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-propyl}-4-(4-methyl-benzyl)-piperidin-4-ol 
• 1361118-23-1 C₁₉H₂₈I₂O₄Si 
• 1361118-22-0 1-(4-((tert-butyldimethylsilyl)oxy)phenyl)-5-(trimethylsilyl)pent-4-yn-2-ol 
• 864160-19-0 2-(4-tert-butyldimethylsiloxyphenyl)propanol 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 215776-67-3 3-[4-(tert-butyl-dimethyl-silanyloxy)phenyl]propan-1-ol 
• 762244-03-1 4-benzyl-1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-methoxy-propyl}-piperidine 
• 375856-67-0 4-(4-bromo-benzyl)-1-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-propyl}-piperidin-4-ol 

Relevant academic research and scientific papers

Oxidative 1,2- and 1,3-alkyl shift processes: Developments and applications in synthesis

Oxidative 1,2- and 1,3- alkyl shifts mediated by a hypervalent iodine reagent were performed on simple and inexpensive phenol derivatives. These transpositions enable rapid redesign of the main aromatic skeleton to generate good yields of highly functionalized scaffolds containing a prochiral dienone system, a quaternary carbon center connected to as many as four sp2 centers, and a carbonyl functionality or precursor. An efficient enantioselective version of this process resulting in the formation of a challenging quaternary carbon center is also described. The products represent the central cores of several natural products having important bioactivities. As an illustration of the potential of this method, we describe the rapid synthesis of several functionalized polycyclic systems as well as a formal synthesis of acetylaspidoalbidine, a hexacyclic alkaloid belonging to the Aspidosperma family.

Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin- 4-ol: A novel NR1/2B subtype selective NMDA receptor antagonist

Starting from Ro-25-6981 as a lead compound, highly potent and selective NR1/2B subtype selective NMDA receptor antagonists, with low activity at α1 adrenergic receptors were developed.

4-HYDROXY-PIPERODINE DERIVATIVES

The present invention relates to compounds of the formula STR1 wherein x is--O--,--NH--,--CH 2--,--CH=,--CO 2--,--CONH--,--CON(lower alkyl)--,--S--and--SO 2--; R. sup.1-R. sup.4 are, independently from each other hydrogen, halogen, hydroxy, amino, nitro, lower-alkyl-sulfonylamido, 1-or 2-imidazolyl, 1-(1,2,4-triazolyl) or acetamido;R 5, R 6 are, independently from each other hydrogen, lower-alkyl, hydroxy, lower alkoxy or oxo;R. sup.7-R 10 are, independently from each other hydrogen, lower-alkyl, halogen, trifluoromethyl or lower-alkoxy;n is 0 or 1; and to pharmaceutically acceptable acid addition salts thereof. Compounds of the present invention are NMDA(N-methyl-D-aspartate)-receptor subtype selective blockers.