22260-83-9

Upstream product

• 67-56-1 methanol 
• 79-37-8 oxalyl dichloride 
• 2198-64-3 N-benzoyl-L-alanine 
• 24762-04-7 2-Diazo-3-oxo-butyric acid methyl ester 
• 55-21-0 benzamide 
• 1404376-54-0 (E)-3-amino-1-methoxy-1-oxobut-2-en-2-yl benzoate 
• 14205-39-1 methyl 3-aminocrotonate 
• 105-45-3 acetoacetic acid methyl ester 
• 52169-89-8 2-phenyl-4-methyl-oxazole-5-carbonyl chloride 
• 2198-64-3 N-Benzoylalanine 
• 69582-90-7 (Z)-methyl 3-(benzamido)but-2-enoate 

Downstream Products

• 248924-06-3 (4-methyl-2-phenyloxazol-5-yl)methanol 
• 1160690-70-9 4-bromomethyl-2-phenyl-oxazole-5-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Generation of Dimethyl Sulfoxide Coordinated Thermally Stable Halogen Cation Pools for C?H Halogenation

A method to generate halogen cation pools from the reaction of 1,2-dihaloethanes (hal=Br, I) and dimethyl sulfoxide (DMSO) for C?H halogenation of arenes and heteroarenes was reported. The initial reaction of DMSO and 1,2-dihaloethane generates the sulfur

Aromatic heterocyclic small molecule organic compounds and derivatives, preparation method and medical use

The invention discloses heterocyclic aromatic micromolecule organic compounds as shown in the structural formula (I) and derivatives thereof, or hydrates or pharmaceutically acceptable salts, and a preparation method of the corresponding compounds; the invention also discloses an application of the compounds and pharmaceutical compositions containing the compounds to the treatment of various metabolic syndrome-related diseases. The heterocyclic aromatic micromolecule organic compounds of the invention have excellent treatment effect on metabolic syndromes; experiment results show that the compounds may promote secretion of endogenous GLP-1, and are applicable to the preparation of anti-diabetic and fat-reducing candidate medicaments. Aiming at technical problems of easy degradation and short half life of current medicaments for treating diabetes, the invention provides novel, high-efficient micromolecule compounds for promoting secretion of endogenous GLP-1, and the compounds are applicable to the treatment of metabolic syndrome-related diseases such as diabetes, obesity and the like.

Palladium-catalyzed sequential C-N/C-O bond formations: Synthesis of oxazole derivatives from amides and ketones

A highly efficient method for the synthesis of oxazole derivatives from simple amides and ketones has been established via a Pd(II)-catalyzed sp2 C-H activation pathway in one step. The reaction is supposed to proceed through a C-N bond formation followed by a C-O bond formation closing the ring. Because of the simple and readily available starting materials, easy operation, and high bioactivity of oxazoles, this strategy can be broadly applied to medical chemistry.

Direct β-acyloxylation of enamines via PhIO-mediated intermolecular oxidative C-O bond formation and its application to the synthesis of oxazoles

A direct β-acyloxylation of enamine compounds has been achieved by using iodosobenzene (PhIO) as an oxidant to realize the intermolecular oxidative C(sp2)-O bond formation between enamines and various carboxylic acids, including N-protected amino acids. The transformation tolerates a wide range of functional groups and furnishes a variety of β-acyloxy enamines that can be conveniently converted to oxazole compounds via cyclodehydration.

Direct β-acyloxylation of enamines via PhIO-mediated intermolecular oxidative C-O bond formation and its application to the synthesis of oxazoles

A direct β-acyloxylation of enamine compounds has been achieved by using iodosobenzene (PhIO) as an oxidant to realize the intermolecular oxidative C(sp2)-O bond formation between enamines and various carboxylic acids, including N-protected amino acids. The transformation tolerates a wide range of functional groups and furnishes a variety of β-acyloxy enamines that can be conveniently converted to oxazole compounds via cyclodehydration.

Rhodium carbene routes to oxazoles and thiazoles. Catalyst effects in the synthesis of oxazole and thiazole carboxylates, phosphonates, and sulfones

(Chemical Equation Presented) Dirhodium tetraacetate catalyzed reaction of α-diazo-β-keto-carboxylates and -phosphonates with arenecarboxamides gives 2-aryloxazole-4-carboxylates and 4-phosphonates by carbene N-H insertion and cyclodehydration. In stark contrast, dirhodium tetrakis(heptafluorobutyramide) catalysis results in a dramatic change of regioselectivity to give oxazole-5-carboxylates and 5-phosphonates. α-Diazo-β-ketosulfones behave similarly and give 5-sulfonyloxazoles upon dirhodium tetrakis-(heptafluorobutyramide) catalyzed reaction with carboxamides. The analogous reactions of thiocarboxamides give the corresponding thiazole-5-carboxylates, -phosphonates, and -sulfones. 2009 American Chemical Society.

The rhodium carbene route to oxazoles: A remarkable catalyst effect

Dirhodium tetraacetate catalysed reaction of α-diazo-β-keto- carboxylates and -phosphonates with arenecarboxamides gives 2-aryloxazole-4- carboxylates and 4-phosphonates by carbene N-H insertion and cyclodehydration; in stark contrast, dirhodium tetrakis(

Reaction of N-Benzoyl Amino Acids with Oxalyl Chloride: a Facile Route to 4-Substituted 2-Phenyloxazole-5-carboxylates

N-benzoyl amino acids 1a-g react with excess oxalyl chloride at room temperature followed by addition of alcohols to afford 4-substituted 2-phenyloxazole-5-carboxylates 3a-g.