222712-39-2Relevant academic research and scientific papers
Novel and efficient route for the synthesis of 4-Aryl-substituted 2(5H)-furanones
Thombare, Pravin,Desai, Jigar,Argade, Anil,Gite, Sanjay,Shah, Kiran,Pavase, Laxmikant,Patel, Pankaj
experimental part, p. 2423 - 2429 (2009/12/03)
4-Aryl-substituted 2(5H)-furanones were prepared by reaction of diethylphosphono acetic acid and phenacyl bromides, followed by an intramolecular Horner-Emmons-type cyclization. Both the reactions were carried out in situ to give the desired 4-aryl substituted 2(5H)-furanone derivatives.
Butenolide annelation using a manganese(III) oxidation. A synthesis of 4-arylfuran-2(5H)-ones
Demir, Ayhan S.,Camkerten, Nurettin,Gercek, Zuhal,Duygu, Nese,Reis, Omer,Arikan, Elif
, p. 2441 - 2448 (2007/10/03)
A general procedure was developed for the annelation of a butenolide to an aromatic ketone that highlighted a manganese(III) oxidation of aromatic ketones. The oxidation of aromatic ketones with manganese(III) acetate in the presence of 2-bromoacetic acid or the Mn(II) salt of this carboxylic acid provided a regioselectively convenient synthesis of 2-(2-bromoacetoxy) ketones. An Arbuzov or Wittig reaction of 2-(2-bromoacetoxy) ketones followed by cyclisation furnished 4-arylfuran-2(5H)-ones in good yield.
