22273-75-2

Upstream product

• 26131-96-4 4-methyl-3-phenyl-2-cyclopentenone 
• 102836-27-1 methyl (4R^*,5S^*)-5-methyl-2-oxo-3-phenylcyclopentanecarboxylate 
• 1078-36-0 4-methyl-1-phenyl-4-pentene-1-one 
• 93-55-0 1-phenyl-propan-1-one 
• 2114-36-5 1-bromopropylbenzene 
• 102836-26-0 methyl 3-oxo-5-phenylheptanoate 
• 35553-85-6 (1S,4R,5S)-4-Phenyl-bicyclo[3.1.0]hexan-2-one 
• 104-55-2 3-phenyl-propenal 
• 1360903-33-8 (R)-4-methyl-3-phenylpent-4-enal 

Downstream Products

• 102836-30-6 (2S,3S)-3-Methyl-5-oxo-2-phenyl-cyclopentanecarboxylic acid methyl ester 
• 102836-27-1 (2S,3S)-2-Methyl-5-oxo-3-phenyl-cyclopentanecarboxylic acid methyl ester 

Relevant academic research and scientific papers

Catalytic asymmetric intramolecular hydroacylation with rhodium/phosphoramidite-alkene ligand complexes

Give me a P: An asymmetric intramolecular Rh-catalyzed hydroacylation reaction of pent-4-enals for the preparation of functionalized cyclopentanones in good yield and high enantioselectivity is described (see scheme, DCE=dichloroethane). This process uses rhodium complexes featuring novel modular phosphoramidite-alkene ligands and achiral phosphine coligands. Copyright

Intermolecular Pauson-Khand reactions of cyclopropane: A general synthesis of cyclopentanones

(equation presented) The Pauson-Khand reaction of cyclopropene with a variety of terminal alkynes has been studied. The best reaction conditions involve NMO activation in CH2Cl2 at -35 °C. In this way, 3-substituted-bicyclo[3.1.0]hex-3-en-2-ones have been obtained in good to excellent yields. As a synthetic application, several types of substituted cyclopentenones have been prepared from these cycloadducts by protocols involving conjugate addition and reductive ring opening.

DIASTEREOSELECTION IN RHODIUM-MEDIATED INTRAMOLECULAR C-H INSERTION: PREPARATION OF A TRANS-3,4 DIALKYL CYCLOPENTANE

Transition state analysis suggests that substantial 1,2 asymmetric induction could be observed in the course of rhodium-mediated intramolecular C-H insertion.This analysis succesfully predicts predominant formation of the trans 3,4-dialkyl cyclopentane wh