22280-93-9Relevant academic research and scientific papers
Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study
El-sayed, Sherihan,Metwally, Kamel,El-Shanawani, Abdalla A.,Abdel-Aziz, Lobna M.,El-Rashedy, Ahmed A.,Soliman, Mahmoud E.S.,Quattrini, Luca,Coviello, Vito,la Motta, Concettina
, p. 4760 - 4764 (2017)
A series of quinazolinone-based rhodanine-3-acetic acids was synthesized and tested for in vitro aldose reductase inhibitory activity. All the target compounds displayed nanomolar activity against the target enzyme. Compounds 3a, 3b, and 3e exhibited almo
Novel 2,4- thiazolidinediones: Synthesis, in?vitro cytotoxic activity, and mechanistic investigation
Metwally, Kamel,Pratsinis, Harris,Kletsas, Dimitris
, p. 340 - 350 (2017/04/13)
Two thiazolidinedione scaffolds different in the position of the thiazolidinedione ring in the molecule were tested for in?vitro cytotoxic activity in a panel of human cancer cell lines namely, prostate cancer cells PC-3, breast carcinoma cells MDA-MB-231
