22282-62-8

Usage

Uses

Used in Organic Chemistry:
2-IODO-5-METHYLPYRIDINE is used as a chemical intermediate for the synthesis of various organic compounds. Its unique structure allows it to participate in a wide range of chemical reactions, making it a valuable component in the development of new molecules and materials.
Used in Pharmaceutical Industry:
2-IODO-5-METHYLPYRIDINE is used as a building block in the synthesis of pharmaceutical compounds. Its reactivity and structural features enable the creation of novel drug candidates with potential therapeutic applications.
Used in Material Science:
2-IODO-5-METHYLPYRIDINE is used as a component in the development of new materials with specific properties. Its ability to participate in various chemical reactions allows for the creation of materials with tailored characteristics for use in different industries.
Used in Research and Development:
2-IODO-5-METHYLPYRIDINE is used as a research tool in the exploration of new chemical reactions and processes. Its unique properties make it an interesting subject for study, potentially leading to new discoveries and advancements in the field of chemistry.

Upstream product

• 108-99-6 3-Methylpyridine 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 3510-66-5 2-Bromo-5-methylpyridine 
• 6457-37-0 (3-methylpyridine)BF₃ 

Downstream Products

• 30413-61-7 2-ethynyl-5-methylpyridine 
• 1448017-12-6 5-methyl-2-[2-(5-methylpyridin-2-yl)-6-vinylphenyl]pyridine 

Relevant academic research and scientific papers

Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.

Cheap and easy synthesis of highly functionalized (het)aryl iodides via the aromatic finkelstein reaction

Aryl iodides are superior coupling partners in cross-couplingA- reactions compared to the corresponding chlorides or bromides. Unfortunately, the iodides are much more expensive, if commercially available at all, than the other halides. Thus, it is often mandatory to transform the available bromides into the corresponding iodides. The copper-catalyzed aromatic Finkelstein reaction turned out to be the method of choice to prepare a number of highly functionalized iodo(het)aryls, including pyridines, 2,2′-bipyridines, and chiral compounds. Georg Thieme Verlag Stuttgart? New York.

Complex-induced proximity effect in the regioselective lithiation of pyridine derivatives

The regioselective ring lithiation of BF3-complexed 3-picoline (1a), 3,4-lutidine (1b), and 3,5-lutidine (1c) was studied. The dilithiation of 1a, 1b, and 1c was also investigated to experimentally explore the relative preference of the sites on the substituted pyridine ring for lithiation. The role of the complex-induced proximity effect (CIPE) for inducing lithiation in these moieties was investigated using both experimental and computational studies.

Unprecedented C-6 functionalisation of 3-picoline induced by a methyl to C-6 lithium shift

BuLi-Me2N(CH2)2OLi (BuLi-LiDMAE) promoted the clean C-6 functionalisation of 3-picoline via a methyl to C-6 lithium shift.